International Immunology

International Immunology publishes a broad range of experimental and theoretical studies in molecular and cellular immunology conducted in laboratories throughout the world.

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Featured article - May issue

Improved methods for detecting selection by mutation analysis of Ig V region sequences

As a tool to examine the in vivo antigen-driven B cell V-gene repertoire, Hershberg et al. (p. 683) present improved statistical methodology that helps to eliminate cross-talk between positive and negative selection and increases the predictive power for detecting immunoglobulin-gene selection by antigen. The model also allows for some intrinsic biases of somatic hypermutation.