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International Immunology Advance Access published online on February 17, 2009
International Immunology, doi:10.1093/intimm/dxp007
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© The Japanese Society for Immunology. 2009. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Regulation of NF-{kappa}B-dependent T cell activation and development by MEKK3

Hisaaki Shinohara1, Sho Yamasaki2, Shiori Maeda1, Takashi Saito2 and Tomohiro Kurosaki1,3

1 Laboratory for Lymphocyte Differentiation
2 Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
3 Laboratory for Lymphocyte Differentiation, World Premier International Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan

Correspondence to: T. Kurosaki; E-mail: kurosaki{at}rcai.riken.jp

The serine/threonine kinase MEKK3, also known as mitogen-activated protein kinase kinase kinase 3, is a critical activator of the transcription factor NF-{kappa}B in innate immunity. However, the physiological function of MEKK3 in adaptive immunity is unclear. Here we report that following TCR signaling, MEKK3 positively regulated the kinase, I{kappa}B kinase, leading to NF-{kappa}B activation. T cells lacking MEKK3 were defective in TCR-induced and cytokine-induced responses. Furthermore, T cell-specific deletion of MEKK3 resulted in reduced numbers of thymocytes and peripheral T cells. Thus, our results provide genetic evidence that MEKK3 plays a crucial role in adaptive immunity.

Keywords: development, MEKK3, NF-{kappa}B, signal, T-cell

Transmitting editor: T. Takai

Received 26 November 2008, accepted 16 January 2009.


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