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International Immunology Advance Access published online on January 14, 2008
International Immunology, doi:10.1093/intimm/dxm147
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© The Japanese Society for Immunology. 2008. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Critical role of dendritic cells in determining the Th1/Th2 balance upon Leishmania major infection

Kazutomo Suzue1,2, Seiki Kobayashi3, Tsutomu Takeuchi3, Mamoru Suzuki2 and Shigeo Koyasu1,4

1 Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
2 Department of Parasitology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan
3 Department of Tropical Medicine and Parasitology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
4 Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Kawaguchi 332-0012, Japan

Correspondence to: Correspondence to: S. Koyasu; E-mail: koyasu{at}sc.itc.keio.ac.jp

The onset of Th1 immunity is in part regulated by genetic background. To elucidate the cell type carrying critical factors determining the Th1 response, we employed Rag-2–/– mice on Leishmania major-susceptible BALB/c and -resistant B10.D2 backgrounds. By using bone marrow (BM) chimeras generated by the transplantation of B10.D2 BM cells into BALB/c-Rag-2–/– mice, and vice versa, it was shown that hematopoietic cells carry factors determining the disease outcome and Th1 response against L. major infection. B10.D2-Rag-2–/– mice reconstituted with BALB/c CD4+ T cells exhibited a Th1 response and controlled L. major infection. Wild-type BALB/c mice inoculated with L. major-parasitized B10.D2-Rag-2–/– splenocytes also exhibited a Th1 response and a mild disease outcome, whereas such a Th1 response was not induced when CD11c+ dendritic cells (DCs) were depleted from parasitized B10.D2-Rag-2–/– splenocytes. Th1 response was reconstituted by the addition of L. major-parasitized B10.D2 DCs but not L. major-parasitized BALB/c DCs to DC-depleted parasitized B10.D2-Rag-2–/– splenocytes. These results indicate that DCs determine the outcome of the disease upon L. major infection.

Keywords: antigen-presenting cell, infectious disease, protozoan parasite, Th

Transmitting editor: K. Inaba

Received 23 September 2007, accepted 12 December 2007.


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