Skip Navigation



International Immunology Advance Access published online on December 21, 2007
International Immunology, doi:10.1093/intimm/dxm135
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
20/2/209    most recent
dxm135v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Yoshimura, T.
Right arrow Articles by Yoshida, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yoshimura, T.
Right arrow Articles by Yoshida, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Japanese Society for Immunology. 2007. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Differential roles for IFN-{gamma} and IL-17 in experimental autoimmune uveoretinitis

Takeru Yoshimura1,2, Koh-Hei Sonoda1, Yoshiyuki Miyazaki3, Yoichiro Iwakura4, Tatsuro Ishibashi1, Akihiko Yoshimura2 and Hiroki Yoshida3

1 Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka
2 Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka
3 Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga
4 Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Correspondence to: Correspondence to: Hiroki Yoshida; E-mail: yoshidah{at}med.saga-u.ac.jp

IL-17-producing CD4+ T cells, so called Th17 cells, constitute a newly identified inflammatogenic cell population, which is critically involved in some inflammatory diseases. To explore the role of Th17 cells in murine experimental autoimmune uveoretinitis (EAU), a model of human autoimmune uveitis where Th1 responses predominantly participate in the pathogenesis, IL-17–/– mice were immunized with interphotoreceptor retinoid-binding protein peptide 1–20 for disease induction. Funduscopic examination revealed that EAU was induced in IL-17–/– mice just like in wild-type (WT) mice at early phases of the disease. However, at later/maintenance phases, the severity was significantly reduced in IL-17–/– mice. Expression of IFN-{gamma} and MCP-1 was comparable between WT and IL-17–/– mice during the time course. In vivo blockade of IFN-{gamma} and IL-4 resulted in exacerbation of EAU at later phases with augmented IL-17 production. Taken together, our data demonstrated that IL-17/Th17 participates in the late phases of EAU and also that Th1 and Th17 responses are differentially required for EAU.

Keywords: autoimmunity, cytokines, inflammation, Th1, Th17

Transmitting editor: T. Watanabe

Received 27 April 2007, accepted 22 November 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.