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International Immunology Advance Access published online on August 13, 2007
International Immunology, doi:10.1093/intimm/dxm075
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© The Japanese Society for Immunology. 2007. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Regional IFN{gamma} expression is insufficient for efficacious control of food-borne bacterial pathogens at the gut epithelial barrier

Nadesan Gajendran1,3, Hans-Willi Mittrücker2,3, Karin Bordasch3, Ellen Heinemann3, Markus Koch3 and Stefan H. E. Kaufmann3

1 Present address: Institute of Physiology, Department of Biomedicine Pharmazentrum/Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland
2 Present address: Institute for Immunology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, D-20246 Hamburg, Germany
3 Max Planck Institute for Infection Biology, Department of Immunology, Charitéplatz 1, Berlin, 10117 Germany

Correspondence to: Correspondence to: S. H. E. Kaufmann; E-mail: kaufmann{at}mpiib-berlin.mpg.de

IFN{gamma} is critical for host defence against various food-borne pathogens including Salmonella enterica and Listeria monocytogenes, the causative agents of salmonellosis and listeriosis, respectively. We investigated the impact of regional IFN{gamma} expression at the intestinal epithelial barrier on host invasion by salmonellae and listeriae following oral challenge. Transgenic mice (IFN{gamma}-gut), generated on an IFN{gamma} knock-out (KO) background, selectively expressed IFN{gamma} in the gut driven by the modified liver fatty acid-binding protein (Fabpl4x at –132) promoter. Infections with attenuated S. enterica Typhimurium or with L. monocytogenes did not differ significantly in IFN{gamma}-KO, IFN{gamma}-gut and wild-type mice. Further, Listeria-specific CD4+ and CD8+ T cells were not altered in IFN{gamma}-gut mice. Thus, this model indicates that local IFN{gamma} expression by non-immunological cells in the distal part of the small intestine, caecum and colon is insufficient for prevention of gut penetration by S. enterica Typhimurium and L. monocytogenes.

Keywords: listeriae, salmonellae, transgenic

Transmitting editor: S. Koyasu

Received 18 December 2006, accepted 8 June 2007.


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