International Immunology Advance Access published online on November 21, 2006
International Immunology, doi:10.1093/intimm/dxl125
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1 Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
* To whom correspondence should be addressed. WSX-1 is a subunit of the IL-27R, which plays a critical role in the initiation of Th1 responses. Murine experimental autoimmune uveitis (EAU) is a model of human autoimmune uveitis, in which a Th1 response predominates in the pathogenetic process. To explore the role of WSX-1 in this model, WSX-1-/- mice were immunized with interphotoreceptor retinoid-binding protein peptide 1-20 to induce EAU. We found that the EAU clinical and histological scores were lower in the WSX-1-/- mice up to day 21, whereas after day 21, the EAU scores were the same between the wild-type (WT) and WSX-1-/- mice with both declining at the same rate. In contrast to T lymphocytes from WT mice, WSX-1-/- T lymphocytes on day 9 after immunization failed to produce IFN-
Received July 26, 2006
Accepted October 26, 2006
Article
WSX-1 plays a significant role for the initiation of experimental autoimmune uveitis
Koh-Hei Sonoda 1 *, Takeru Yoshimura 2, Atsunobu Takeda 1, Tatsuro Ishibashi 1, Shinjiro Hamano 3, and Hiroki Yoshida 4
2 Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan; Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan
3 Department of Parasitology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
4 Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Saitama, Japan; Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
Koh-Hei Sonoda, E-mail: sonodak{at}med.kyushu-u.ac.jp
Abstract 
. Similarly, expression of Th1-related chemokines, such as regulated on activation, normal T cell expressed and secreted and IP-10, in the eye was reduced in WSX-1-/- mice compared with WT mice on day 13 after immunization. In addition, sub-retinal transfer of lymphocytes from WSX-1-/- mice on day 9 after immunization did not induce EAU in the recipient mice. Importantly, IFN- production, chemokine expression and the transferability of disease by lymphocytes became comparable for WSX-1-/- and WT mice at later stages. Thus, IL-27/WSX-1 affects the early development of EAU, and might be a target for therapy during the onset of autoimmune uveitis in humans.
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