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International Immunology Advance Access published online on September 20, 2006
International Immunology, doi:10.1093/intimm/dxl093
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© The Japanese Society for Immunology. 2006. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
Received March 22, 2006
Accepted August 25, 2006

Article

Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells

Afonso R. M. Almeida 1, Bruno Zaragoza 2, and Antonio A. Freitas 2 *

1 Lymphocyte Population Biology Unit, URA CNRS 1961, Institut Pasteur, 28 Rue du Dr. Roux, 75015 Paris, France; Present address: Institute for Research in Biomedicine, Bellinzona, Switzerland
2 Lymphocyte Population Biology Unit, URA CNRS 1961, Institut Pasteur, 28 Rue du Dr. Roux, 75015 Paris, France

* To whom correspondence should be addressed.
Antonio A. Freitas, E-mail: afreitas{at}pasteur.fr


  Abstract

Recent reports have hinted that it is possible to regenerate CD4+CD25+ regulatory T cells (Treg) from CD4+CD25- cells, a phenomenon termed conversion. We evaluated the relative contribution of this process to the Treg pool by transferring purified populations of CD4+ T cells into T cell-deficient mice. We report that conversion of CD25- cells into the CD4+CD25+Treg pool is minor if other bona fide CD25+ Tregs are present. Moreover, in the same hosts, the loss of CD25 expression by a population of Tregs also decreases in the presence of co-injected CD4+CD25- cells. Thus, the rate of exchange between CD25- and CD25+ T-cell populations is determined by the presence or absence of T-cell competitors. Our results attest for the role of competition in the contribution of different T-cell subsets for the regeneration of the peripheral CD4+ T-cell pool during lymphopenia.

Keywords: IL-2; lymphopenia-driven proliferation; regulatory T cells; T-cell homeostasis.
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