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International Immunology Advance Access published online on September 20, 2006
International Immunology, doi:10.1093/intimm/dxl091
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© The Japanese Society for Immunology. 2006. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
Received May 4, 2006
Accepted August 23, 2006

Article

The 8.1 ancestral MHC haplotype is associated with delayed onset of colonization in cystic fibrosis

Judit Laki 1 *, István Laki 2, Krisztina Németh 3, Rita Újhelyi 4, Olga Bede 5, Emoke Endreffy 5, Katalin Bolbás 2, Kálmán Gyurkovits 2, Eszter Csiszér 6, Eniko Sólyom 7, Gergely Dobra 2, Adrienn Halász 8, Éva Pozsonyi 9, Katalin Rajczy 9, Zoltán Prohászka 1, György Fekete 3, and George Füst 10

1 Third Department of Medicine, Semmelweis University, 1125 Budapest, Kútvölgyi út 4, Hungary; Research Group of Atherosclerosis and Metabolism, Hungarian Academy of Sciences, 1125 Budapest, Kútvölgyi út 4, Hungary
2 Department of Pediatrics, Hospital for Chest Diseases of the Reformed Church of Hungary, 7257 Mosdós, Petofi u. 4, Hungary
3 Second Department of Pediatrics, Semmelweis University, 1094 Budapest, Tuzoltó u. 7-9, Hungary
4 Department of Pediatric Pulmonology, Heim Pál Children's Hospital, 1089 Budapest, Ülloi út 86, Hungary
5 Department of Pediatrics, University of Szeged, Albert Szent-Györgyi Medical School, 6725 Szeged, Korányi Fasor 14-15, Hungary
6 Third Department of Pulmonology, National Korányi Institute for TB and Pulmonology, 1529 Budapest, Piheno út 1, Hungary
7 Department of Pediatric Gastroenterology, Borsod-A-Z County and University Teaching Hospital, Pediatric Health Centre, 3526 Miskolc, Szentpéteri kapu 72-76, Hungary
8 Department of Pediatric Pulmonology (III), Svabhegy Children's Hospital, 1121 Budapest, Mártonhegyi út 6, Hungary
9 National Medical Center, Institute of Haematology and Immunology, 1113 Budapest, Daróci u. 24, Hungary
10 Third Department of Medicine, Semmelweis University, 1125 Budapest, Kútvölgyi út 4, Hungary; Szentágothai János Knowledge Center, Semmelweis University, Budapest, Ülloi út 26, Hungary

* To whom correspondence should be addressed.
Judit Laki, E-mail: lakij{at}kut.sote.hu


  Abstract

Major cause of death in patients with cystic fibrosis (CF) is colonization with Staphylococcus aureus and Pseudomonas aeruginosa. The wide phenotypic variation in CF patients suggests that genes other than the cystic fibrosis transmembrane conductance regulator (CFTR) gene modify the disease. The 8.1 ancestral haplotype (8.1AH) in main histocompatibility complex is associated with alterations of the immune response. To study the influence of carriage of 8.1AH on frequency and onset of colonization in CF patients, DNA samples of 72 CF patients (39 homozygous and 33 heterozygous for {Delta}F508) were genotyped for member alleles of the 8.1AH: HLA-DQB1*0201, HLA-DRB1*0301, receptor for advanced glycation end products (AGER) -429C, HSP70-2 -1267G (HSP70-2G) and tumor necrosis factor-{alpha} (TNF-{alpha}) -308A (TNF2). Colonization was verified by regular clinical and bacteriological screening. Frequency of colonization was significantly (P = 0.012) lower in the 8.1AH carriers; age, gender and {Delta}F508 genotype-adjusted odds ratio to be colonized of the carriers versus non-carriers was 0.112 (0.024-0.520). According to survival analysis, patients with 8.1AH had significantly (P < 0.0001) longer colonization-free period compared with non-carriers. Our novel observations demonstrate that the 8.1AH is associated with delayed onset of colonization in CF, presumably by influencing defense mechanisms against infections.

Keywords: cystic fibrosis; HLA; infection; MHC; TNF-{alpha}.
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