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International Immunology Advance Access published online on November 15, 2005
International Immunology, doi:10.1093/intimm/dxh346
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© The Japanese Society for Immunology. 2005. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
Received March 31, 2005
Accepted October 4, 2005

Article

B cell development in aging mice: lessons from mathematical modeling

Gitit Shahaf 1, Kara Johnson 2, and Ramit Mehr 1 *

1 Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel
2 Abott Laboratories, Abott Park, IL 60064, USA

* To whom correspondence should be addressed.
Ramit Mehr, E-mail: mehrra{at}mail.biu.ac.il


  Abstract

Previous studies have not completely clarified the precise defect that characterizes B cell development in aged animals. The question of which developmental mechanism is actually deficient in aging remains controversial. The goal of this study was to elucidate the effects of aging on bone marrow B cell population dynamics. We used mathematical modeling to predict the outcome of the different possible effects, and then compared these predictions to experimental data, to find the most plausible effects. Our model shows that the three main differences between B cell development in young and old mice are a decrease in the maximum number of cells in the pre-B compartment and increases in the rate of transition from cycling pre-B cells to resting pre-B cells and in the fractions of static cells included in the immature B cell subset.

Keywords: B lymphocytes; computer simulations; immunosenescence; repertoire development.
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