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International Immunology Advance Access published online on September 20, 2004
International Immunology, doi:10.1093/intimm/dxh160
© 2004 by The Japanese Society for Immunology
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Received October 29, 2003
Accepted August 20, 2004

Article

Phenotypic and functional deficiencies of monocyte-derived dendritic cells in systemic lupus erythematosus (SLE) patients

Marcus Köller 1, Bettina Zwölfer 1, Günter Steiner 1, Josef S. Smolen 1, and Clemens Scheinecker 1*

1 Department of Rheumatology, Internal Medicine III, Medical University of Vienna, General Hospital of Vienna, Währingergürtel 18-20, A-1090 Vienna, Austria

* To whom correspondence should be addressed. E-mail: clemens.scheinecker{at}meduniwien.ac.at.


  Abstract

Systemic lupus erythematosus (SLE) represents an autoimmune disease for which alterations of T cells, B cells as well as various antigen-presenting cell (APC) populations have been described. In order to better define APC-associated deficiencies, we analyzed morphologic, phenotypic and functional characteristics of in vitro-generated monocyte-derived dendritic cells (MoDC) from SLE patients as compared with healthy controls. Analysis of MoDC at different stages of maturation revealed substantial phenotypic and functional defects of MoDC from SLE patients as compared with healthy controls. In particular, we observed a significantly reduced up-regulation of MHC class II molecules on MoDC upon activation which correlated with disease activity scores and functional deficiencies in mixed lymphocyte reaction experiments. Our data imply a crucial role of APC in the immunological imbalance in SLE for foreign and self-antigen reactivity.

Keywords: SLE; dendritic cells; monocytes; toll-like receptors.
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