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International Immunology Advance Access published online on September 6, 2004
International Immunology, doi:10.1093/intimm/dxh154
© 2004 by The Japanese Society for Immunology
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Received March 11, 2004
Accepted August 2, 2004

Article

Antigen-independent acquisition of MHC class II molecules by human T lymphocytes

Anita H. Undale 1, Peter J. van den Elsen 2, and Esteban Celis 1*

1 Department of Immunology, Mayo Clinic, Rochester, MN, USA
2 Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands

* To whom correspondence should be addressed. E-mail: celis.esteban{at}mayo.edu.


  Abstract

We report here that human T lymphocytes have the capacity of acquiring large amounts of MHC class II molecules from various types of antigen-presenting cells (APC) in an antigen-independent manner. The transfer of MHC class II molecules from APC to T cell required direct cell-to-cell contact and appeared to involve the interaction of numerous adhesion molecules between these cells. Depletion of cholesterol from the plasma membrane reduced the amount of MHC class II transferred onto the T cells. Most significantly, the newly acquired MHC class II molecules were capable of efficiently presenting antigen to T helper cells. These results suggest that T cells are able to interact with other T cells to regulate immune responses by presenting MHC peptide complexes that have been snatched away from nearby APC.

Keywords: adhesion molecules; antigen presentation; MHC; T lymphocytes; trogocytosis.
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