International Immunology Advance Access published online on August 31, 2004
International Immunology, doi:10.1093/intimm/dxh152
© 2004 by The Japanese Society for Immunology
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1 Third Department of Internal Medicine, Semmelweis University and Hungarian Academy of Sciences, Budapest, Hungary; Research Group of Metabolism and Atherosclerosis, Semmelweis University and Hungarian Academy of Sciences, Budapest, Hungary
* To whom correspondence should be addressed. E-mail: FustGe{at}kut.sote.hu.
The genetic basis for addiction to tobacco smoking--particularly that of the perception of olfactory stimuli that may be important in reinforcing smoking addiction--is largely unknown. A cluster of genes for olfactory receptors is in close proximity to the MHC region on chromosome 6. Polymorphisms of MHC class III genes (RCCX modules, TNFA promoter polymorphisms) were determined in 101 healthy subjects and 232 coronary artery disease (CAD) patients from Hungary with defined tobacco smoking habits. A highly significant association between ever smoking (past + current smokers) and a specific MHC haplotype was observed (odds ratios = 2.14-4.13; P-values = 0.012 to <0.001). This haplotype is characterized by the presence of C4A null alleles and a solitary short C4B gene linked to the TNF2 allele of the promoter for TNFA gene. This haplotype occurred more frequently in the ever smokers than in the never smokers [odds ratio: 4.97 (1.96-12.62); P = 0.001], and such associations were stronger in women (odds ratio = 13.6) than in men (odds ratio = 2.79). An independent study of complement C4 protein polymorphism and smoking habits in Icelandic subjects (n = 351) yielded similar and confirmative results. Considering the documented link between olfactory stimuli and smoking in females, and the presence of a cluster of odorant receptor genes close to the MHC class I region, our findings implicate a potential role of the MHC-linked olfactory receptor genes in the initiation of smoking.
Accepted July 28, 2004
Article
Genetic basis of tobacco smoking: strong association of a specific major histocompatibility complex haplotype on chromosome 6 with smoking behavior
Duba 5,
2 Department of Immunology, Institute for Medical Laboratory Sciences, Landspítali University Hospital, Reykjavík, Iceland
3 Central Laboratory, St John Hospital, Budapest, Hungary
4 Heim Pál Pediatric Hospital, Budapest, Hungary
5 National Institute of Cardiology, Budapest, Hungary
6 Center for Molecular and Human Genetics, Columbus Children's Research Institute and College of Medicine and Public Health, The Ohio State University, Columbus, Ohio, USA
7 Tissue Typing Laboratory, Finnish Red Cross Blood Transfusion Service and Transplantation Laboratory, University of Helsinki, Helsinki, Finland
8 Department of Medicine, Landspitali University Hospital, Reykjavík, Iceland
9 Third Department of Internal Medicine, Semmelweis University and Hungarian Academy of Sciences, Budapest, Hungary
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