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International Immunology Advance Access published online on August 16, 2004
International Immunology, doi:10.1093/intimm/dxh144
© 2004 by The Japanese Society for Immunology
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Received February 18, 2004
Accepted July 15, 2004

Article

BAZF is required for activation of naive CD4 T cells by TCR triggering

Mikio Takamori 1, Masahiko Hatano 2, Masafumi Arima 2, Akemi Sakamoto 2, Lisa Fujimura 2, Tety Hartatik 2, Takayuki Kuriyama 3, Takeshi Tokuhisa 2*

1 Department of Developmental Genetics (H2), Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8670, Japan; Department of Respirology (B2), Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8670, Japan
2 Department of Developmental Genetics (H2), Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8670, Japan
3 Department of Respirology (B2), Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8670, Japan

* To whom correspondence should be addressed. E-mail: tokuhisa{at}faculty.chiba-u.jp.


  Abstract

BAZF, a member of the Bcl6 gene family, acts as a sequence-specific transcriptional repressor in association with Bcl6. However, the tissue expression pattern of BAZF differs from that of Bcl6, suggesting a Bcl6-independent function of BAZF. In order to examine the physiological function of BAZF, we generated BAZF-deficient mice and transgenic mice with BAZF-cDNA under the control of the lck proximal promoter (lck-BAZF). These mice were viable and no gross anatomical abnormalities were observed after birth. Since Bcl6 is a key molecule for the generation of memory T cells, we examined the function of T cells of these mice. We show here that cell proliferation of naive CD4 T cells, but not memory ones, of BAZF-deficient mice to anti-CD3 antibody stimulation was impaired. Conversely, cell proliferation of naive CD4 T cells, but not memory ones, of lck-BAZF mice was augmented. Since cell proliferation of naive CD4 T cells of lck-Bcl6 mice to anti-CD3 antibody stimulation was severely impaired, BAZF may attenuate the regulatory effect of Bcl6 on antigenic activation of naive CD4 T cells by Bcl6/BAZF heterodimer formation. These results suggest that BAZF is necessary for activation of naive T cells to antigenic stimulation.

Keywords: cellular activation; knockout; T cell receptor; T lymphocytes; transcription factors; transgenic.
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