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International Immunology Advance Access published online on July 19, 2004
International Immunology, doi:10.1093/intimm/dxh125
© 2004 by The Japanese Society for Immunology
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Received September 20, 2003
Accepted June 11, 2004

Article

CD4+ T cells are important for clearance of DA strain of TMEV from the central nervous system of SJL/J mice

Xiaoqi Lin 1, Xiaoxing Ma 1, Moses Rodriguez 2, Raymond P. Roos 1*

1 Department of Neurology, University of Chicago, Chicago, IL 60637, USA
2 Departments of Neurology and Immunology, Mayo Clinic, Rochester, MN 55905, USA

* To whom correspondence should be addressed. E-mail: rroos{at}neurology.bsd.uchicago.edu.


  Abstract

DA and other TO subgroup strains of Theiler's murine encephalomyelitis virus synthesize a protein called L* which interferes with DA virus clearance from the central nervous system of susceptible SJL mice, thereby fostering virus persistence and a late demyelinating disease. By using CD4 (-/-) and CD8 (-/-) mice as well as adoptive transfer studies we demonstrate that susceptible mouse strains are capable of clearing DA virus through a CD4+ T cell-dependent activity that is inhibited by L*.

Keywords: anti-virus immunity; immune-mediated demyelination.
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