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International Immunology Advance Access published online on June 7, 2004
International Immunology, doi:10.1093/intimm/dxh103
© 2004 by The Japanese Society for Immunology
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Received December 27, 2003
Accepted April 26, 2004

Article

Involvement of FcR{gamma} in signal transduction of osteoclast-associated receptor (OSCAR)

Satoru Ishikawa 1, Noriko Arase 2, Tadashi Suenaga 1, Yoshitomo Saita 3, Masaki Noda 3, Takayuki Kuriyama 4, Hisashi Arase 5*, Takashi Saito 2

1 Department of Molecular Genetics, Chiba University Graduate School of Medicine, Chiba, Japan
2 Department of Molecular Genetics, Chiba University Graduate School of Medicine, Chiba, Japan; Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
3 Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
4 Department of Respirology, Chiba University Graduate School of Medicine, Chiba, Japan
5 Department of Molecular Genetics, Chiba University Graduate School of Medicine, Chiba, Japan; Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3-1, Suita, Osaka 565-0871, Japan; PRESTO, Japan Science and Technology Agency, Saitama, Japan

* To whom correspondence should be addressed. E-mail: arase{at}biken.osaka-u.ac.jp.


  Abstract

Osteoclasts regulate homeostasis of bone development. A defect in osteoclast development results in osteopetrosis. Recently, the involvement of several molecules in osteoclast development has been found. Osteoclast-associated receptor (OSCAR) is one of such molecules critical for osteoclast differentiation. However, it remains unclear how OSCAR transduces signals for osteoclast differentiation. Here, we found that the FcR{gamma} chain, a signal transducing adaptor molecule for Fc receptors, is associated with OSCAR and is involved in the cell surface expression of OSCAR. Furthermore, FcR{gamma} is required for signal transduction by OSCAR. These findings suggest that the FcR{gamma}-mediated signal transduction by OSCAR is involved in osteoclast differentiation.

Keywords: CD3{zeta}, Fc receptor, Ig-like receptor, ITAM, osteoclast


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