International Immunology Advance Access published online on June 1, 2004
International Immunology, doi:10.1093/intimm/dxh102
© 2004 by The Japanese Society for Immunology
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1 Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2-2, Yamada-oka, Suita, Osaka, 565-0871, Japan
* To whom correspondence should be addressed. E-mail: a.kimura{at}imed3.med.osaka-u.ac.jp.
Suppressor of cytokine signaling-1 (SOCS-1) was identified as one of the negative feedback regulators of Janus kinase (Jak)-signal-transducer-and-activator-of-transcription (STAT) signaling. So far, it has been reported that SOCS-1 inhibits the action of multiple cytokines at least in vitro. We previously showed that SOCS-1 suppresses tumor necrosis factor- Keywords:
caspase, cell death, negative feedback regulator, TNFR-1, tyrosine kinase
Accepted April 20, 2004
Article
SOCS-1 suppresses TNF-
-induced apoptosis through the regulation of Jak activation
2 Department of Genetics, Osaka University Medical School, 2-2, Yamada-oka, Suita, Osaka, 565-0871, Japan
3 Laboratory of Immune Regulation, Graduate School of Frontier Biosciences, Osaka University, 1-3, Yamada-oka, Suita, Osaka, 565-0871, Japan
Abstract 
(TNF-)-induced apoptosis in murine embryonic fibroblast, but the mechanism of suppression was not fully clarified. In this study, we show that Jaks bind to TNF receptor-1 (TNFR-1) and are activated by TNF-. We also show that the activations of Jaks and caspases by TNF- are suppressed by SOCS-1. Furthermore, in Jak-deficient cell lines, DNA fragmentation and caspase-8 activation by TNF- are suppressed, indicating that Jaks participate in TNF--induced apoptosis signaling. Taken together, these results suggest that SOCS-1 inhibits TNF--induced apoptosis through regulation of Jaks.
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