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International Immunology Advance Access published online on May 4, 2004
International Immunology, doi:10.1093/intimm/dxh085
© 2004 by The Japanese Society for Immunology
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Received April 26, 2003
Accepted March 14, 2004

Article

Duplicated copies of the bovine JH locus contribute to the Ig repertoire

Arsalan Hosseini 1, Gordon Campbell 2, Marko Prorocic 2, Robert Aitken 2*

1 Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz 71345, Iran
2 Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK

* To whom correspondence should be addressed. E-mail: r.aitken{at}bio.gla.ac.uk.


  Abstract

We report the cloning and analysis of a bovine JH locus comprising a DQ52 segment, six JH segments and sequence to a 5' H chain intronic enhancer. The contig was mapped to BTA 11 and evidence was found for rearrangement of the sixth JH segment at a low but detectable frequency. In contrast, the fourth segment present at a second copy of the bovine JH locus mapping to BTA 21 was found to rearrange at high-frequency, forming FR4 in the majority of bovine Ig H chains. The data thus show that bovine H chains can be generated from segments at two distinct genomic locations. Further investigation should establish if rearrangement takes place at each locus or if the participating segments are brought together from different chromosomal locations by less conventional processes (for example by gene conversion or trans-chromosomal rearrangement).

Keywords: antibodies, J genes, joining, rearrangement


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