International Immunology, Vol 9, 263-271, Copyright © 1997 by Oxford University Press
J Fillion, R Baccala, C Pannetier, J Kuhn, P Druet and B Bellon
Administration of subtoxic doses of HgCl2 affects differentially the immune
system depending on the strain of rats tested. Susceptible Brown- Norway
(BN) rats exhibit a CD4+ T cell-dependent polyclonal activation of B cells;
in contrast, Lewis (LEW) rats are resistant and develop an
immunosuppression mediated by CD8+ T cells recruited by CD4+ T cells. The
mechanisms by which mercury induces immune disorders are poorly understood.
We were interested in analyzing the diversity and mercury- mediated changes
of the TCR Vbeta repertoire in the BN and LEW strains of rats at different
times of HgCl2 exposure. Our results obtained after analysis of lymph node
T cells by RNase protection assay, flow cytometry or immunoscope assay (i)
were not consistent with a superantigen-like stimulus since we observed
neither a V beta-selective expansion nor deletion that would have been
expected and (ii) showed that in BN rats, as well as in LEW rats, an
increase in the number of T cells was associated with the heterogeneous TCR
V beta repertoire, thus supporting a polyclonal T cell activation. However,
in BN rats the total number of T cells increased very rapidly, whereas in
LEW rats only CD8+ T cells accumulated.
ARTICLES
Evidence for heterogeneous TCR V beta repertoire expression in mercury- induced immune disorders in rats
INSERM U430, Hopital Broussais, Paris, France.
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