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International Immunology, Vol. 5, No. 11, pp. 1461-1471,November 1993
© 1993 Japanese Society for Immunology

Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

Fiona Powrie, Michael W. Leach1, Smita Mauze, Linda Barcomb Caddie and Robert L. Coffman

DNAX Research Institute of Molecular and Cellular Biology Inc. 901 California Ave., Palo Alto, CA 94040, USA
1 Schering-Plough Research Institute PO Box 32, Route 94, Lafayette, NJ 07848, USA

Correspondence to: Correspondence to: F. Powrie

CD4+ T cells in the mouse can be subdivided into two fractions based on the level of expression of the CD45RB determinant. Previous studies have shown that these subsets are functionally distinct. We have further characterized the properties of these subpopulations in vivo by injecting them into C. B-17 scid mice. The animals restored with the CD45RBhighCD4+ T cell population developed a lethal wasting disease with severe mononuclear cell infiltrates into the colon and elevated levels of IFN-{gamma} mRNA. In contrast, animals restored with the reciprocal CD45RBlow subset or with unfractionated CD4+ T cells did not develop the wasting or colitis. Importantly, the co-transfer of the CD45RBlow population with the CD45RBhigh population prevented the wasting disease and colitis. These data indicate that important regulatory interactions occur between the CD45RBhigh and CD45RBlowCD4+ T cell subsets and that disruption of this mechanism has fatal consequences.

Keywords: CD45, CD4+ T cell subsets, colitis, immunoregulation, inflammation

Received 1 June 1993, accepted 13 August 1993.


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