International Immunology, Vol. 5, No. 11, pp. 1461-1471,November 1993
© 1993 Japanese Society for Immunology
Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice
DNAX Research Institute of Molecular and Cellular Biology Inc. 901 California Ave., Palo Alto, CA 94040, USA
1 Schering-Plough Research Institute PO Box 32, Route 94, Lafayette, NJ 07848, USA
Correspondence to: Correspondence to: F. Powrie
CD4+ T cells in the mouse can be subdivided into two fractions based on the level of expression of the CD45RB determinant. Previous studies have shown that these subsets are functionally distinct. We have further characterized the properties of these subpopulations in vivo by injecting them into C. B-17 scid mice. The animals restored with the CD45RBhighCD4+ T cell population developed a lethal wasting disease with severe mononuclear cell infiltrates into the colon and elevated levels of IFN-
mRNA. In contrast, animals restored with the reciprocal CD45RBlow subset or with unfractionated CD4+ T cells did not develop the wasting or colitis. Importantly, the co-transfer of the CD45RBlow population with the CD45RBhigh population prevented the wasting disease and colitis. These data indicate that important regulatory interactions occur between the CD45RBhigh and CD45RBlowCD4+ T cell subsets and that disruption of this mechanism has fatal consequences.
Keywords: CD45, CD4+ T cell subsets, colitis, immunoregulation, inflammation
Received 1 June 1993, accepted 13 August 1993.
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C Veltkamp, R B Sartor, T Giese, F Autschbach, I Kaden, R Veltkamp, D Rost, B Kallinowski, and W Stremmel Regulatory CD4+CD25+ cells reverse imbalances in the T cell pool of bone marrow transplanted TG{varepsilon}26 mice leading to the prevention of colitis Gut, February 1, 2005; 54(2): 207 - 214. [Abstract] [Full Text] [PDF]
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 M. T Cantorna, Y. Zhu, M. Froicu, and A. Wittke Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system Am. J. Clinical Nutrition, December 1, 2004; 80(6): 1717S - 1720S. [Abstract] [Full Text] [PDF]
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K. Kitamura, Y. Nakamoto, S. Kaneko, and N. Mukaida Pivotal roles of interleukin-6 in transmural inflammation in murine T cell transfer colitis J. Leukoc. Biol., December 1, 2004; 76(6): 1111 - 1117. [Abstract] [Full Text] [PDF]
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S. You, C. Chen, W.-H. Lee, T. Brusko, M. Atkinson, and C.-P. Liu Presence of Diabetes-Inhibiting, Glutamic Acid Decarboxylase-Specific, IL-10-Dependent, Regulatory T Cells in Naive Nonobese Diabetic Mice J. Immunol., December 1, 2004; 173(11): 6777 - 6785. [Abstract] [Full Text] [PDF]
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T. Dohi, K. Fujihashi, T. Koga, Y. Etani, N. Yoshino, Y. I. Kawamura, and J. R. McGhee CD4+CD45RBHi Interleukin-4 Defective T Cells Elicit Antral Gastritis and Duodenitis Am. J. Pathol., October 1, 2004; 165(4): 1257 - 1268. [Abstract] [Full Text] [PDF]
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B. E. Anderson, J. M. McNiff, C. Matte, I. Athanasiadis, W. D. Shlomchik, and M. J. Shlomchik Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease Blood, September 1, 2004; 104(5): 1565 - 1573. [Abstract] [Full Text] [PDF]
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M. Drakes, T. Blanchard, and S. Czinn Bacterial Probiotic Modulation of Dendritic Cells Infect. Immun., June 1, 2004; 72(6): 3299 - 3309. [Abstract] [Full Text] [PDF]
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T.-C. Chen, S. P. Cobbold, P. J. Fairchild, and H. Waldmann Generation of Anergic and Regulatory T Cells following Prolonged Exposure to a Harmless Antigen J. Immunol., May 15, 2004; 172(10): 5900 - 5907. [Abstract] [Full Text] [PDF]
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 M. Schultz, U. G. Strauch, H.-J. Linde, S. Watzl, F. Obermeier, C. Gottl, N. Dunger, N. Grunwald, J. Scholmerich, and H. C. Rath Preventive Effects of Escherichia coli Strain Nissle 1917 on Acute and Chronic Intestinal Inflammation in Two Different Murine Models of Colitis Clin. Vaccine Immunol., March 1, 2004; 11(2): 372 - 378. [Abstract] [Full Text] [PDF]
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 Y. P. de Jong, S. T. Rietdijk, W. A. Faubion, A. C. Abadia-Molina, K. Clarke, E. Mizoguchi, J. Tian, T. Delaney, S. Manning, J.-C. Gutierrez-Ramos, et al. Blocking inducible co-stimulator in the absence of CD28 impairs Th1 and CD25+ regulatory T cells in murine colitis Int. Immunol., February 1, 2004; 16(2): 205 - 213. [Abstract] [Full Text] [PDF]
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P. Zhou, R. Borojevic, C. Streutker, D. Snider, H. Liang, and K. Croitoru Expression of Dual TCR on DO11.10 T Cells Allows for Ovalbumin-Induced Oral Tolerance to Prevent T Cell-Mediated Colitis Directed against Unrelated Enteric Bacterial Antigens J. Immunol., February 1, 2004; 172(3): 1515 - 1523. [Abstract] [Full Text] [PDF]
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J. S. Bryson, L. Zhang, S. W. Goes, C. D. Jennings, B. E. Caywood, S. L. Carlson, and A. M. Kaplan CD4+ T Cells Mediate Murine Syngeneic Graft-versus-Host Disease-Associated Colitis J. Immunol., January 1, 2004; 172(1): 679 - 687. [Abstract] [Full Text] [PDF]
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M.-A. Alyanakian, S. You, D. Damotte, C. Gouarin, A. Esling, C. Garcia, S. Havouis, L. Chatenoud, and J.-F. Bach Diversity of regulatory CD4+T cells controlling distinct organ-specific autoimmune diseases PNAS, December 23, 2003; 100(26): 15806 - 15811. [Abstract] [Full Text] [PDF]
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 M. Froicu, V. Weaver, T. A. Wynn, M. A. McDowell, J. E. Welsh, and M. T. Cantorna A Crucial Role for the Vitamin D Receptor in Experimental Inflammatory Bowel Diseases Mol. Endocrinol., December 1, 2003; 17(12): 2386 - 2392. [Abstract] [Full Text] [PDF]
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A. Foussat, F. Cottrez, V. Brun, N. Fournier, J.-P. Breittmayer, and H. Groux A Comparative Study between T Regulatory Type 1 and CD4+CD25+ T Cells in the Control of Inflammation J. Immunol., November 15, 2003; 171(10): 5018 - 5026. [Abstract] [Full Text] [PDF]
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 C. V. Whiting, J. F. Tarlton, M. Bailey, C. L. Morgan, and P. W. Bland Abnormal Mucosal Extracellular Matrix Deposition Is Associated with Increased TGF-{beta} Receptor-expressing Mesenchymal Cells in a Mouse Model of Colitis J. Histochem. Cytochem., September 1, 2003; 51(9): 1177 - 1189. [Abstract] [Full Text] [PDF]
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T. L. Denning, H. Qi, R. Konig, K. G. Scott, M. Naganuma, and P. B. Ernst CD4+ Th Cells Resembling Regulatory T Cells That Inhibit Chronic Colitis Differentiate in the Absence of Interactions Between CD4 and Class II MHC J. Immunol., September 1, 2003; 171(5): 2279 - 2286. [Abstract] [Full Text] [PDF]
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K. Uraushihara, T. Kanai, K. Ko, T. Totsuka, S. Makita, R. Iiyama, T. Nakamura, and M. Watanabe Regulation of Murine Inflammatory Bowel Disease by CD25+ and CD25- CD4+ Glucocorticoid-Induced TNF Receptor Family-Related Gene+ Regulatory T Cells J. Immunol., July 15, 2003; 171(2): 708 - 716. [Abstract] [Full Text] [PDF]
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C. Asseman, S. Read, and F. Powrie Colitogenic Th1 Cells Are Present in the Antigen-Experienced T Cell Pool in Normal Mice: Control by CD4+ Regulatory T Cells and IL-10 J. Immunol., July 15, 2003; 171(2): 971 - 978. [Abstract] [Full Text] [PDF]
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 K. Asadullah, W. Sterry, and H. D. Volk Interleukin-10 Therapy--Review of a New Approach Pharmacol. Rev., June 1, 2003; 55(2): 241 - 269. [Abstract] [Full Text] [PDF]
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C. S. Bonder and P. Kubes The Future of GI and Liver Research: Editorial Perspectives: II. Modulating leukocyte recruitment to splanchnic organs to reduce inflammation Am J Physiol Gastrointest Liver Physiol, May 1, 2003; 284(5): G729 - G733. [Abstract] [Full Text] [PDF]
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C. Mottet, H. H. Uhlig, and F. Powrie Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells J. Immunol., April 15, 2003; 170(8): 3939 - 3943. [Abstract] [Full Text] [PDF]
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T. Oida, X. Zhang, M. Goto, S. Hachimura, M. Totsuka, S. Kaminogawa, and H. L. Weiner CD4+CD25- T Cells That Express Latency-Associated Peptide on the Surface Suppress CD4+CD45RBhigh-Induced Colitis by a TGF-{beta}-Dependent Mechanism J. Immunol., March 1, 2003; 170(5): 2516 - 2522. [Abstract] [Full Text] [PDF]
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T. Barthlott, G. Kassiotis, and B. Stockinger T Cell Regulation as a Side Effect of Homeostasis and Competition J. Exp. Med., February 17, 2003; 197(4): 451 - 460. [Abstract] [Full Text] [PDF]
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