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International Immunology 2009 21(3):NP; doi:10.1093/intimm/dxp022
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© The Japanese Society for Immunology. 2009. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

IN THIS ISSUE

The first 10% of the full text of this article appears below.


   IL-7 and HIV Tat synergise to downregulate IL-7R{alpha}
 
IL-7 is crucial for many T cell responses, and downregulation of the IL-7R{alpha} chain (CD127) impairs these functions. Using CD8+ cells from healthy volunteers, MacPherson and colleagues (p. 203) show that physiological amounts of IL-7 and HIV Tat synergise to downregulate CD127; on the other hand, Tat opposes IL-7-induced cell proliferation. The authors discuss the possible molecular mechanisms . . . [Full Text of this Article]


   Naloxone — a novel adjuvant?
 

   ZEB1 recruits repressor proteins to the IL-2 gene
 

   DNase I levels in SLE
 

   Evolution of NKp44 in primates
 

   Immune regulation by Prdx5 splice isoforms
 

   GM-CSF is tolerogenic for CD8{alpha}– DCs
 

   HIV-1 binds Tregs and enhances their activity
 

   The Notch ligand Dll1 affects DC and B cell homeostasis
 

   A role for fibulin 6 in Sjörgen's syndrome?
 

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