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International Immunology 2008 20(7):NP; doi:10.1093/intimm/dxn067
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© The Japanese Society for Immunology. 2008. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

IN THIS ISSUE

The first 10% of the full text of this article appears below.


    Matrix metalloproteinases and NK cell cytotoxicity
 
Ligation of receptors such as NKG2D on NK cells to ligands on tumour cells can trigger cytotoxicity. In this issue, Mami-Chouaib and colleagues (p. 801) show that matrix metalloproteinases (MMPs) can enable lung cancer cell lines to shed the ligands and escape killing. Using MMP inhibitors, perhaps in combination with IL-15, might circumvent this evasion mechanism.


    Bam32 activates Erk in T cells
 
B lymphocyte adapter molecule of 32 kD (Bam32) is known to be involved in BCR-mediated signalling. Here, Samelson and colleagues . . . [Full Text of this Article]


    Levels of CD45 isoforms and T cell signalling
 

    Activation of {gamma}{delta} cells by a probiotic
 

    The phenotype of alloreactive killer cells
 

    Two pathways for Th1 generation by mycobacteria
 

    Regulatory T cells in SLE
 

    NKT cells break CTL tolerance to HBV
 

    Constitutive TLR-mediated B cell activation in lupus
 

    Oral antigens reduce numbers of T cells
 

    Signalling pathways in keratinocyte antiviral responses
 

    S1P1 agonism impairs dendritic cell migration
 

    ICAT is important for thymocyte development
 

    MHC-restricted suppression by CD8+CD122+ Tregs
 

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