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International Immunology Advance Access originally published online on January 8, 2008
International Immunology 2008 20(2):185-192; doi:10.1093/intimm/dxm132
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© The Japanese Society for Immunology. 2008. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Physiological up-regulation of inhibitory receptors Fc{gamma}RII and CR1 on memory B cells is lacking in SLE patients

Andrea Isaák1, Péter Gergely, Jr2, Zsuzsanna Szekeres3, József Prechl1, Gyula Poór2, Anna Erdei1,3 and János Gergely1,3

1 Research Group of the Hungarian Academy of Sciences, Eötvös Loránd University, Pázmány Péter s. 1/C, Budapest H-1117, Hungary
2 Institute of Rheumatology and Physiotherapy, Frankel Leo u.25-29, Budapest H-1023, Hungary
3 Department of Immunology, Eötvös Loránd University, Pázmány Péter s. 1/C, Budapest H-1117, Hungary

Correspondence to: A. Erdei; E-mail: anna.erdei{at}freemail.hu

Under physiological conditions immune complexes (IC) are efficiently cleared from the circulation and meanwhile provide important feedback signals for the immune system via Fc{gamma}Rs and complement receptors. Dysregulation of these mechanisms have been implicated in conditions where IC concentrations reach pathological levels and inflict diseases, like systemic lupus erythematosus (SLE). Our aim was to compare distinct sub-populations of CD19+ B cells of healthy individuals and SLE patients with regard to their expression of Fc{gamma}R type II (Fc{gamma}RII, CD32), complement receptor type 1 (CR1, CD35) and complement receptor type 2 (CR2, CD21) and sIgG/IgM. The following four groups of peripheral CD19+ B cells were investigated: IgM+/CD27– naive, IgM+/CD27+ and IgM–/CD27+ memory cells and CD27high plasmablasts. We demonstrate that the expression of the inhibitory receptors Fc{gamma}RII and CR1 is up-regulated on peripheral memory B cells of healthy controls, whereas this up-regulation is considerably impaired on the memory B cells of SLE patients. This reduction affects both the IgM+ and switched memory B cells. We found a striking difference between the expression of complement receptors CD21 and CD35; namely, no up-regulation of CD21 occurred on the memory B cells of healthy donors, and its decreased expression in SLE patients was characteristic for both the CD27– naive and the CD27+ memory B-cell populations. Our results clearly demonstrate that the previously reported reduced expression of IC-binding receptors is mainly due to the disturbed memory compartment; however, the higher frequency of CD19+/CD27high/sIglow plasmablasts expressing minimal levels of these receptors also contributes to this diminution.

Keywords: autoimmunity, IC-binding receptors

Transmitting editor: A. Falus

Received 27 October 2007, accepted 6 November 2007.


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