International Immunology Advance Access originally published online on November 21, 2006
International Immunology 2007 19(1):93-98; doi:10.1093/intimm/dxl125
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
WSX-1 plays a significant role for the initiation of experimental autoimmune uveitis
1 Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
2 Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan
3 Department of Parasitology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
4 Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Saitama, Japan
5 Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
Correspondence to: K.-H. Sonoda; E-mail: sonodak{at}med.kyushu-u.ac.jp
WSX-1 is a subunit of the IL-27R, which plays a critical role in the initiation of Th1 responses. Murine experimental autoimmune uveitis (EAU) is a model of human autoimmune uveitis, in which a Th1 response predominates in the pathogenetic process. To explore the role of WSX-1 in this model, WSX-1–/– mice were immunized with interphotoreceptor retinoid-binding protein peptide 1–20 to induce EAU. We found that the EAU clinical and histological scores were lower in the WSX-1–/– mice up to day 21, whereas after day 21, the EAU scores were the same between the wild-type (WT) and WSX-1–/– mice with both declining at the same rate. In contrast to T lymphocytes from WT mice, WSX-1–/– T lymphocytes on day 9 after immunization failed to produce IFN-
. Similarly, expression of Th1-related chemokines, such as regulated on activation, normal T cell expressed and secreted and IP-10, in the eye was reduced in WSX-1–/– mice compared with WT mice on day 13 after immunization. In addition, sub-retinal transfer of lymphocytes from WSX-1–/– mice on day 9 after immunization did not induce EAU in the recipient mice. Importantly, IFN- production, chemokine expression and the transferability of disease by lymphocytes became comparable for WSX-1–/– and WT mice at later stages. Thus, IL-27/WSX-1 affects the early development of EAU, and might be a target for therapy during the onset of autoimmune uveitis in humans.
Keywords: autoimmunity, cytokine, eye, IL-27, Th1
Transmitting editor: T. Watanabe
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Yoshimura, K.-H. Sonoda, N. Ohguro, Y. Ohsugi, T. Ishibashi, D. J. Cua, T. Kobayashi, H. Yoshida, and A. Yoshimura Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis Rheumatology, April 1, 2009; 48(4): 347 - 354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yoshimura, K.-H. Sonoda, Y. Miyazaki, Y. Iwakura, T. Ishibashi, A. Yoshimura, and H. Yoshida Differential roles for IFN-{gamma} and IL-17 in experimental autoimmune uveoretinitis Int. Immunol., February 1, 2008; 20(2): 209 - 214. [Abstract] [Full Text] [PDF]
|
|