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International Immunology Advance Access originally published online on November 13, 2006
International Immunology 2007 19(1):1-10; doi:10.1093/intimm/dxl117
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© The Japanese Society for Immunology. 2006. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells

Ulla-Angela Temann1, Yasmina Laouar1, Elizabeth E. Eynon1,2, Robert Homer3,4 and Richard A. Flavell1,2

1 Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
2 Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
3 Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
4 Pathology and Laboratory Medicine Service, VA Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT 06511, USA

Correspondence to: R. A. Flavell; E-mail: richard.flavell{at}yale.edu

Constitutive expression of IL9 in the lungs of transgenic (Tg) mice resulted in an asthma-like phenotype consisting of lymphocytic and eosinophilic lung inflammation, mucus hypersecretion and mast cell hyperplasia. Several Th2 cytokines including IL4, IL5 and IL13 were expressed in the lung in response to Tg IL9. IL13 was absolutely necessary for the development of lung pathology. To understand how IL9 induces IL13-dependent lung inflammation and mucus production, we sought the IL13-producing cells. Surprisingly, we found that the absence of T cells and B cells in recombinase-activating gene 1 (RAG1)-deficient IL9 Tg mice enhanced lung inflammation and dramatically enhanced IL13 production. In addition, the lack of mast cells or eosinophils in IL9 Tg mice did not affect IL13 levels in the lung. In situ hybridization for IL13 on lung sections from RAG1–/– IL9 Tg mice revealed that airway epithelial cells were the major IL13-producing cell type. Our results implicate the lung epithelium as a potentially important source of inflammatory cytokines in asthma.

Keywords: asthma, cytokines, IL9, IL13


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