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International Immunology Advance Access originally published online on April 18, 2005
International Immunology 2005 17(6):713-719; doi:10.1093/intimm/dxh251
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© The Japanese Society for Immunology. 2005. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org

Functional re-expression of CCR7 on CMV-specific CD8+ T cells upon antigenic stimulation

Ester M. M. van Leeuwen1,2, Jaap D. van Buul3, Ester B. M. Remmerswaal1, Peter L. Hordijk3, Ineke J. M. ten Berge2 and Rene A. W. van Lier1

1 Department of Experimental Immunology, 2 Department of Internal Medicine, Divisions of Nephrology and Clinical Immunology and Rheumatology, Academic Medical Center Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands and 3 Department of Experimental Immunohematology, Sanquin Research at CLB, Amsterdam, The Netherlands

Correspondence to: E. M. M. van Leeuwen; E-mail: e.m.vanleeuwen{at}amc.uva.nl

During latency circulating human cytomegalovirus (CMV)-specific CD8+ T cells do not express the chemokine receptor CCR7. We here show that antigen-specific stimulation in vitro with the specific CMV-peptide in combination with CMV-antigen, IL-2 or IL-21 induced re-expression of CCR7 on CMV-specific CD8+ T cells. Although IL-15 induced strong proliferation of peptide-pulsed CMV-specific CD8+ T cells, these cells did not re-express CCR7. CMV-specific cells that re-expressed CCR7 also expressed CD62L and were able to react to specific chemokine stimulation with changes in the cytoskeleton. In addition, activated CMV-specific cells specifically migrated towards a chemokine gradient in a transwell assay, with and without an endothelial cell monolayer. We conclude that antigenic stimulation induced functional re-expression of CCR7 which suggests that the migratory properties of virus-primed T cells are flexible and depend on the presence or absence of antigen and cytokines.

Keywords: CD8+ memory T cells, chemokine receptor, cytomegalovirus, human, migration

Transmitting editor: C. Terhorst


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