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International Immunology Advance Access originally published online on May 20, 2005
International Immunology 2005 17(6):677-684; doi:10.1093/intimm/dxh238
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© The Japanese Society for Immunology. 2005. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org

Aberrant gene expression by CD25+CD4+ immunoregulatory T cells in autoimmune-prone rats carrying the human T cell leukemia virus type-I gene

Hiroko Hayase1, Akihiro Ishizu1, Hitoshi Ikeda1,3, Yukiko Miyatake1, Tomohisa Baba1, Masato Higuchi1, Asami Abe1, Utano Tomaru1 and Takashi Yoshiki1,2

1 Department of Pathology/Pathophysiology, Division of Pathophysiological Science, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan
2 Genetic Lab, Co., Ltd, Kita-9, Nishi-15, Chuo-ku, Sapporo 060-0009, Japan
3 Present address: Section of Pathology, Hakodate Central General Hospital, Hakodate 040-8585, Japan

Correspondence to: A. Ishizu; E-mail: aishizu{at}med.hokudai.ac.jp

Transgenic rats expressing the env-pX gene of human T cell leukemia virus type-I under the control of the viral long terminal repeat promoter (env-pX rats) developed systemic autoimmune diseases. Prior to disease manifestation, the immunosuppressive function of CD25+CD4+ T (T-reg) cells was impaired in these rats. Since T cell differentiation appeared to be disordered in env-pX rats, we assumed that the impairment of T-reg cells might be caused by an abortive differentiation in the thymus. However, reciprocal bone marrow transfers between env-pX and wild-type rats revealed that direct effects of the transgene unrelated to the thymus framework induced the abnormality of T-reg cells. To identify molecular changes, comparative analyses were done between env-pX and wild-type T-reg cells. Expression of the Foxp3 gene and cell-surface markers supported a naive phenotype for env-pX T-reg cells. Array analyses of gene expression showed some interesting profiles, e.g. up-regulation of genes associated with the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathways in env-pX T-reg cells. Additionally, expression of the suppressor of cytokine signaling (SOCS) family genes, which inhibit the JAK/STAT signals, was extremely low in env-pX T-reg cells. These findings suggest that the transgene may mediate the down-regulation of the SOCS family genes and that subsequent excess signals through the JAK/STAT pathways may result in the loss of function of env-pX T-reg cells. We suggest that investigation of the pathology of T-reg cells in our autoimmune-prone rat model may aid in understanding the roles of T-reg cells in human autoimmune diseases.

Keywords: animal model, Foxp3, JAK/STAT, SOCS, T-reg

Transmitting editor: K. Okumura


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