Skip Navigation


International Immunology Advance Access originally published online on December 27, 2004
International Immunology 2005 17(2):117-122; doi:10.1093/intimm/dxh191
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Material
Right arrow All Versions of this Article:
17/2/117    most recent
dxh191v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (2)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Pascolo, S.
Right arrow Articles by Rammensee, H.-G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pascolo, S.
Right arrow Articles by Rammensee, H.-G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© 2004 The Japanese Society for Immunology

The non-classical HLA class I molecule HFE does not influence the NK-like activity contained in fresh human PBMCs and does not interact with NK cells

Steve Pascolo1, Florent Ginhoux2, Nihay Laham3, Steffen Walter1, Oliver Schoor1, Jochen Probst1, Pierre Rohrlich4,5, Florian Obermayr1, Paul Fisch6, Olivier Danos2, Rachel Ehrlich3, Francois A. Lemonnier4 and Hans-Georg Rammensee1

1 Department of Immunology, Auf der Morgenstelle 15, 72076 Tübingen, Germany
2 Genethon CNRS UMR 8115, 1 bis rue de l'Internationale, BP60, Evry Cedex 91002, France
3 Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel
4 Immunité Cellulaire Antivirale, Institut Pasteur, 28 rue du Dr. Roux, 75715 Paris, France
5 Hospital Robert Debré, 75019 Paris, France
6 Pathologisches Institut, University of Freiburg, Freiburg, Germany

Correspondence to: S. Pascolo; E-mail: steve.pascolo{at}uni-tuebingen.de

In humans, four ß2-microglobulin-associated non-classical class I molecules are encoded in the MHC: HLA-E, -F, -G and -H. Three of them (HLA-E, -F and -G) were shown to inhibit NK activity. On the contrary, the fourth one, HLA-H, named HFE after it was found to be mutated in patients suffering from inherited hemochromatosis, has been shown to be involved only in the regulation of iron uptake. We tested the capacity of HFE to affect (enhance or reduce) specifically the NK activity contained in non-manipulated fresh human PBMCs. We showed that HFE expression by target cells does not affect their killing by the NK-like activity contained in PBMCs. Moreover, using fluorescent HFE tetramers, we could confirm that blood NK cells as well as blood {gamma}{delta} T cells do not bind HFE. Altogether, our data indicate that HFE does not affect the NK activity contained in the PBMCs.

Keywords: HFE, iron metabolism, NK cells, non-classical MHC class I, tetramer

Transmitting editor: E. Vivier


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.