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International Immunology Advance Access originally published online on October 11, 2005
International Immunology 2005 17(12):1543-1552; doi:10.1093/intimm/dxh331
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© The Japanese Society for Immunology. 2005. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Physical and functional interactions between STAT3 and ZIP kinase

Noriko Sato1, Taro Kawai2, Kenji Sugiyama3, Ryuta Muromoto1, Seiyu Imoto1, Yuichi Sekine1, Masato Ishida3, Shizuo Akira2 and Tadashi Matsuda1

1 Department of Immunology, Graduate School of Pharmaceutical Sciences Hokkaido University, Kita-Ku Kita 12 Nishi 6, Sapporo 060-0812, Japan
2 Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan
3 Nippon Boehringer Ingelheim Co., Ltd, Kawanishi Pharma Research Institute, 3-10-1 Yato, Kawanishi, Hyogo 666-0193, Japan

Correspondence to: T. Matsuda; E-mail: tmatsuda{at}pharm.hokudai.ac.jp

Signal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic transcription factor that can be activated by cytokines and growth factors. It plays important roles in cell growth, apoptosis and cell transformation, and is constitutively active in a variety of tumor cells. In this study, we provide evidence that zipper-interacting protein kinase (ZIPK) interacts physically with STAT3. ZIPK specifically interacted with STAT3, and did not bind to STAT1, STAT4, STAT5a, STAT5b or STAT6. ZIPK phosphorylated STAT3 on serine 727 (Ser727) and enhanced STAT3 transcriptional activity. Small interfering RNA-mediated reduction of ZIPK expression decreased leukemia inhibitory factor (LIF)- and IL-6-induced STAT3-dependent transcription. Furthermore, LIF- and IL-6-mediated STAT3 activation stimulated ZIPK activity. Taken together, our data suggest that ZIPK interacts with STAT3 within the nucleus to regulate the transcriptional activity of STAT3 via phosphorylation of Ser727.

Keywords: IL-6, LIF, signal transduction, STAT3, ZIP kinase

Transmitting editor: T. Hirano


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