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International Immunology Advance Access originally published online on October 7, 2005
International Immunology 2005 17(11):1367-1378; doi:10.1093/intimm/dxh318
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© The Japanese Society for Immunology. 2005. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Review Article

Regulation of the type I IFN induction: a current view

Kenya Honda, Hideyuki Yanai, Akinori Takaoka and Tadatsugu Taniguchi

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan

Correspondence to: T. Taniguchi; E-mail: tada{at}m.u-tokyo.ac.jp

The type I IFN-{alpha}/ß gene family was identified about a quarter of a century ago as a prototype of many cytokine gene families, which led to the subsequent burst of studies on molecular mechanisms underlying cytokine gene expression and signaling. Although originally discovered for their activity to confer an antiviral state on cells, more evidence has recently been emerging regarding IFN-{alpha}/ß actions on cell growth, differentiation and many immunoregulatory activities, which are of even greater fundamental biological significance. Indeed, much attention has recently been focused on the induction and function of the IFN-{alpha}/ß system regulated by Toll-like receptors (TLRs), which are critical for linking the innate and adaptive immunities. The understanding of the regulatory mechanisms of IFN-{alpha}/ß gene induction by TLRs and viruses is an emerging theme, for which much new insight has been gained over the past few years.

Keywords: antiviral immunity, host defense, interferon, IRF, plasmacytoid dendritic cell, Toll-like receptor

Transmitting editor: H. Kikutani


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