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International Immunology Advance Access originally published online on August 9, 2004
International Immunology 2004 16(9):1323-1332; doi:10.1093/intimm/dxh135
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© 2004 The Japanese Society for Immunology

Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice

Elma Z. Tchilian, Ritu Dawes, Lisa Hyland, Maria Montoya, Agnes Le Bon, Persephone Borrow, Sam Hou, David Tough and Peter C. L. Beverley

The Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, UK

Correspondence to: E. Tchilian; E-mail: elma.tchilian{at}jenner.ac.uk

Transgenic mice have been constructed expressing high (CD45RABC) and low (CD45R0) molecular weight CD45 isoforms on a CD45–/– background. Phenotypic analysis and in vivo challenge of these mice with influenza and lymphocytic choriomeningitis viruses shows that T cell differentiation and peripheral T cell function are related to the level of CD45 expression but not to which CD45 isoform is expressed. In contrast, B cell differentiation is not restored, irrespective of the level of expression of a single isoform. All CD45 trangenic mice have T cells with an activated phenotype and increased T cell turnover. These effects are more prominent in CD8 than CD4 cells. The transgenic mice share several properties with humans expressing variant CD45 alleles and provide a model to understand immune function in variant individuals.

Keywords: CD45, CD45 isoforms, CD45 polymorphism, viral infection

The first two authors contributed equally to this paper.

Transmitting editor: H. R. MacDonald


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