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International Immunology Advance Access originally published online on June 14, 2004
International Immunology 2004 16(8):1081-1090; doi:10.1093/intimm/dxh109
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© 2004 The Japanese Society for Immunology

ORIGINAL RESEARCH PAPERS

Screening of alternative models for transitional B cell maturation

Gitit Shahaf1, David Allman2, Michael P. Cancro2 and Ramit Mehr1

1 Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel
2 Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 231 John Morgan Building, 36th and Hamilton Walk, Philadelphia, PA 19104-6082, USA

Correspondence to: R. Mehr; E-mail: mehrra{at}mail.biu.ac.il

Several functional and phenotypic B cell populations have been described in the spleen. These include the ‘transitional’ subsets, which are thought to be late differentiation intermediates of marrow-derived, mature follicular B cells. The exact progenitor–successor relationships of these transitional subsets, as well as whether a proliferative step is requisite for follicular B cell maturation, remain controversial. Moreover, whether late B cell differentiation might involve branched or asynchronous maturation pathways, thus allowing some cells to ‘skip’ one or more of these stages, has not been investigated. Herein we have used mathematical modeling to interrogate these possibilities. Using mathematical models that numerically simulate splenic B cell population dynamics, we have determined which alternative models of differentiation best fit existing in vivo labeling data. Our results indicate that follicular differentiation does not involve a proliferating splenic intermediate. Our results further suggest that some developing cells move directly from the immature marrow pool to more advanced semi-mature peripheral subsets without passing through the least mature subset in the spleen.

Keywords: mathematical model, population dynamics, transitional B lymphocyte subsets

Transmitting editor: I. Pecht


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[Abstract] [Full Text] [PDF]


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