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International Immunology Advance Access originally published online on August 31, 2004
International Immunology 2004 16(10):1515-1522; doi:10.1093/intimm/dxh153
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© 2004 The Japanese Society for Immunology

AILIM/ICOS signaling induces T-cell migration/polarization of memory/effector T-cells

Naokazu Okamoto1,2, Yuko Nukada1,2, Katsunari Tezuka3, Kazumasa Ohashi4, Kensaku Mizuno4 and Takashi Tsuji1,2

1 Department of Biological Science and Technology, Faculty of Industrial Science and Technology and 2 Tissue Engineering Research Center, Research Institute of Biological Science, Tokyo University of Science, Yamazaki 2641, Noda, Chiba, 278-8510, Japan
3 Pharmaceutical Research Laboratory, JT Inc., Takatsuki, Osaka 569-1125, Japan
4 Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi 980-8578, Japan

Correspondence to: T. Tsuji; E-mail: t-tsuji{at}rs.noda.tus.ac.jp

AILIM/ICOS has critical roles in the regulation of T-cell differentiation and effector T-cell function in various immune responses. The counter-ligand for AILIM/ICOS, B7h, is widely expressed in not only lymphoid tissue and antigen-presenting cells, but also in fibroblast and endothelial cells in various organs. Here, we demonstrate that activated human T-cells migrate beneath TNF-{alpha}-treated HUVEC and display morphological polarization via AILIM/ICOS signaling. AILIM/ICOS stimulation, in the absence of antigen stimulation, also induced T-cell polarization. Importantly, AILIM/ICOS-mediated polarization was evident in CD4+CD45RO+ memory T-cells and generated Th1 cells, but not in CD4+CD45RA+ naive T-cells and generated Th2 cells. Furthermore, AILIM/ICOS signaling is involved in transendothelial migration of Th1 cells, but not Th2 cells. Our data suggest that AILIM/ICOS–B7h interactions play an important role in the endothelium in controlling the entry of memory/effector T-cells into inflamed tissues in the periphery.

Keywords: costimulatory molecule/inflammation/transendothelial migration

The first two authors contributed equally to this work.

Transmitting editor: K. Sugamura


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