Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (24)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Langman, R. E.
Right arrow Articles by Cohn, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Langman, R. E.
Right arrow Articles by Cohn, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

International Immunology, Vol. 15, No. 5, pp. 593-609, May 2003
© 2003 Japanese Society for Immunology

A computerized model for the self–non-self discrimination at the level of the Th (Th genesis). II. The behavior of the system upon encounter with non-self antigens

Rodney E. Langman{dagger},1, James J. Mata1 and Melvin Cohn1

1 Conceptual Immunology Group, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA

{dagger}Dr Rodney Eric Langman passed away on 13 August 2002 after a long and courageous struggle with lung cancer
Correspondence to: M. Cohn; E-mail: cohn{at}salk.edu
Transmitting editor: S. M. Hedrick

In the final analysis, the self (S)–non-self (NS) discrimination is regulated by the sufficiency or insufficiency of effector Th (eTh) specific for the given antigen. We have described a model (Th genesis) for the origin of eTh based on an antigen-independent pathway from initial state Th (iTh) to eTh, and on obligatory associative recognition of antigen (ARA) by an iTh and an eTh in order for the iTh to be activated. A computer analysis (referred to as Th genesis) was developed to evaluate this model that is extended here to describe the response to NS antigen. Th genesis fills in the missing element of the two-signal or ARA model for the S–NS discrimination, i.e. the origin of the primer eTh. The conclusions from this analysis are compared with those of the other models for the origin of eTh.

Keywords: autoimmunity, computer simulation, immunopathology, origin of effector Th, self–non-self discrimination, tolerance, two-signal model


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Int ImmunolHome page
M. Cohn
What roles do regulatory T cells play in the control of the adaptive immune response?
Int. Immunol., September 1, 2008; 20(9): 1107 - 1118.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.