International Immunology, Vol. 15, No. 2, pp. 215-221,
February 2003
© 2003 Japanese Society for Immunology
Essential role for Vav1 in activation, but not development, of 
T cells
1 The Center for Blood Research, 2 Howard Hughes Medical Institute, 3 Department of Pediatrics, The Children’s Hospital, 4 Department of Pathology, Medicine and Molecular Biology, Massachusetts General Hospital, and 5 Department of Genetics, Harvard Medical School, Boston, MA 02115, USA 6 Present address: Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
Correspondence to: F. W. Alt, The Children’s Hospital, Howard Hughes Medical Institute, 320 Longwood Avenue, Boston, MA 02115, USA; E-mail: alt{at}rascal.med.harvard.edu
Transmitting editor: K. M. Murphy
Vav1 is a guanine nucleotide exchange factor essential in the development and function of 
ß lineage T cells. Here we report that in contrast to profound effects on pre-TCR- or ß TCR-dependent events in thymocyte development, Vav1 deficiency has no detectable effect on the development of 
T cells. Strikingly, however, these T cells are markedly deficient in signaling through the TCR, as evidenced by a lack of proliferation and cytokine production in response to stimulation with anti- TCR antibodies. We propose that Vav1 has a unique and non-redundant role in the initiation of signaling downstream of the TCR in lymphocytes.
Keywords: antigen receptor, lymphocyte activation, lymphocyte development, intestinal epithelial lymphocyte, Vav1
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