International Immunology, Vol. 14, No. 6, pp. 535-544,
June 2002
© 2002 Japanese Society for Immunology
A potential role for CD69 in thymocyte emigration
1 Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, 2 Experimental Transplantation and Immunology Branch, National Cancer Institute, and 3 Laboratory of Molecular and Cellular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA 4 Division of Hematologic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Correspondence to: P. E. Love; E-mail: pel{at}helix.nih.gov
Transmitting editor: P. Ohashi
The early activation marker, CD69, is transiently expressed on activated mature T cells and on thymocytes that are undergoing positive or negative selection in the thymus. CD69 is a member of the NK gene complex family of C-type lectin-like signaling receptors; however, its function is unknown. In this report, we describe the characterization of mice that constitutively express high levels of surface CD69 on immature and mature T cells throughout development. Constitutive surface expression of CD69 did not affect T cell maturation, signaling through the TCR or thymocyte selection. However, phenotypically and functionally mature thymocytes accumulated in the medulla of CD69 transgenic mice and failed to be exported from the thymus. The retention of mature thymocytes correlated with transgene dose and CD69 surface levels. These results identify a potential role for CD69 in controlling thymocyte export, and suggest that the transient expression of CD69 on thymocytes and T cells may function to regulate thymocyte and T cell trafficking.
Keywords: CD69 antigen, development, lymphocyte activation, transgenes
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