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International Immunology, Vol. 14, No. 10, pp. 1203-1213, October 2002
© 2002 Japanese Society for Immunology

Global reprogramming of dendritic cells in response to a concerted action of inflammatory mediators

Malin Lindstedt1, Bengt Johansson-Lindbom1 and Carl A. K. Borrebaeck1

1 Department of Immunotechnology, Lund University, PO Box 7031, 220 07 Sweden

Correspondence to: C. A. K. Borrebaeck; E-mail: carl.borrebaeck{at}immun.lth.se
Transmitting editor: P. W. Kincade

Maturation of dendritic cells (DC) serves a deterministic role in the link between innate and adaptive immunity, constituting a checkpoint with regard to whether responses from the lymphocyte compartment shall be raised and what class of response is needed to protect the host against invading pathogens. Since DC have not been shown to possess mechanisms such as gene recombination or somatic mutation for generating a diverse repertoire of antigen-recognition receptors, it is unlikely that these leukocytes can intrinsically respond to all conceivable molecules present in our environment. In the present study, we have therefore determined how mediators of the inflammatory response regulate global gene transcription in DC. The data represent an extensive and time-ordered reprogramming of the DC during their course of maturation, involving genes encoding proteins that regulate responses of both innate cells and lymphocytes. This transcriptional reorganization may reflect the effect of in vivo released inflammatory mediators induced by endogenous or pathogenic stimulation.

Keywords: cellular activation, dendritic cell, immunomodulator, inflammation, inflammatory mediator


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