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International Immunology, Vol. 13, No. 7, 863-870, July 2001
© 2001 Japanese Society for Immunology

The peptide-specific alloreactive human T cell repertoire varies largely between individuals and is not extended in HLA-A*0205–anti-HLA-A*0201 pairings

Arnaud Moris,1, Dorothee Wernet,2, Stefan Stevanovic and Hans-Georg Rammensee Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany
2 Department of Transfusion Medicine, Otfried-Müller-Straße 4/1, 72076 Tübingen, Germany

Correspondence to: H.-G. Rammensee

Alloreactive T cells recognize framework or peptide-dependent determinants on foreign MHC molecules. Among the peptide-dependent alloreactive T cells a significant proportion is specific for one particular peptide presented by the allo-MHC molecule as antigen-specific T cells would do. Such alloreactive, peptide-specific T cells are referred to as `allorestricted'. High-avidity HLA-A*02 allorestricted cytotoxic T lymphocyte (CTL) clones specific for peptide libraries can be generated from HLA-A*02– donors. We made use of this technique to study the role of closely related self-HLA molecules on shaping of the alloreactive T cell repertoire. Peripheral blood lymphocytes from HLA-A*0205 individuals were stimulated by HLA-A*0201 targets pulsed with an HLA-A*0201 peptide library. We did not observe a bias towards peptide-specific CTL in the HLA-A*0201-directed alloreactive repertoire of HLA-A*0205 donors as compared to HLA-A*02– donors. Comparison of the alloreactive T cell response between two donors having similar HLA haplotypes demonstrated that the allorestricted T cell repertoire is largely different between individuals.

Keywords: alloreactivity, allorestriction, immunotherapy, positive selection, T cell repertoire

1 Present address: Retrovirus and Gene Transfer, Pasteur Institute, 28 rue du Dr. Roux, 75724 Paris Cedex 15, France

Transmitting editor: T. Sasazuki


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