International Immunology, Vol. 12, No. 9, 1347-1351,
September 2000
© 2000 Japanese Society for Immunology
Activation-induced expression of murine CD83 on T cells and identification of a specific CD83 ligand on murine B cells
Bernhard-Nocht-Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, 20359 Hamburg, Germany
Correspondence to: A. von Bonin
Human CD83 is a cell surface protein expressed predominantly by dendritic cells (DC) and lymphoid cells. So far, there exists no information on the function and distribution of mCD83. Here we demonstrate that mCD83 is moderately expressed on resting T cells and DC, but strongly increases in its expression on T cells following activation with antigenic peptides or T cell receptor-specific mAb. When returning to the resting state, T cells down-regulate CD83 again. Ig fusion proteins which express the extracellular part of the mCD83 molecule (mCD83–Ig) specifically inhibit antigen-specific T cell proliferation and IL-2 secretion in spleen cell cultures from DO11.10 T cell receptor transgenic mice. Staining of spleen cells from BALB/c, XID and µMT (B cell) knockout mice with mCD83–Ig proteins reveals the presence of a CD83 ligand predominantly expressed most likely by B220+ cells since spleen cells from µMT knockout mice do not bind mCD83–Ig. CD83, besides its established expression on human dendritic cells, thus, also represents a new marker molecule on activated T cells which with its specific ligand is involved in the regulation of T cell responses.
Keywords: CD83, dendritic cells, T cell activation
Published data contain the main parts of S. C.'s PhD thesis
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