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International Immunology, Vol. 11, No. 5, 739-744, May 1999
© 1999 Japanese Society for Immunology

Co-ligation of CD44 on naive human tonsillar B cells induces progression towards a germinal center phenotype

Sigurdur Ingvarsson, Katarina Dahlenborg, Roland Carlsson1 and Carl A. K. Borrebaeck

Department of Immunotechnology, Lund University, Box 7031, 220 07 Lund, Sweden
1 BioInvent Therapeutic AB, SE-223 70 Lund, Sweden

Correspondence to: C. A. K. Borrebaeck

The precise signaling pathways to induce a germinal center (GC) phenotype and somatic mutations in human B cells are presently not understood. Major phenotypical hallmarks of a human GC B cell are up-regulated expression of CD10 and CD95 together with a heterogeneous expression of CD77. Activation of resting human tonsillar B cells using anti-CD40 and anti-IgM antibodies normally only induces up-regulation of CD38 and CD71 but has no effect on the typical GC markers. However, we show here that an additional co-ligation of the glycoprotein CD44 on such tonsillar B cells up-regulated the typical human GC markers CD10, CD38, CD77 and CD95, and down-regulated CD24 and CD39 as well as induced progression towards apoptosis in these cells; all characteristics of GC B cells. These data indicate a functional role of CD44 during activation of human naive B lymphocytes and in the generation of GC B cells.

Keywords: B cell differentiation, germinal centers

Transmitting editor: H. Wigzell


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