International Immunology, Vol. 11, No. 5, 643-655,
May 1999
© 1999 Japanese Society for Immunology
IL-7 receptor 
+ CD3– cells in the embryonic intestine induces the organizing center of Peyer's patches
Department of Molecular Genetics, Faculty of Medicine,
1 Department of Molecular Biology, Institute of Genetics and
2 Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Syogoin-Kawaharacho 53, Sakyoku, Kyoto 606-8507, Japan
Correspondence to: H. Yoshida
Peyer's patch (PP) organogenesis proceeds through three histologically distinct steps: formation of organizing centers expressing VCAM-1 and ICAM-1 in segregated regions of the intestine at 15.5 days post-coitus (d.p.c.) (step I), accumulation of blood cells expressing different sets of surface markers to this region at 16.5–17.0 d.p.c. (step II), and entry of CD3+ and B220+ lymphocytes just before birth (step III). PP formation of both Il7ra–/– and Lta–/– mice is impaired from step I, suggesting involvement of the two molecules at the same timing in PP organogenesis. Expression of lymphotoxin (LT) 
and LTß in IL-7 receptor (IL-7R) + cells in the intestine indicates that defects of Il7ra–/– and Lta–/– mice are due to functional inability of IL-7R+ cells in the induction of PP anlage. Blocking of IL-7R function by a single injection of the antagonistic mAb in 15.5 d.p.c. embryos suppressed appearance of VCAM-1+ spots and expression of LT and LTß in the intestine, which eventually resulted in mice without PP but are otherwise normal. Intestinal IL-7R+ cells are lymphoid in morphology but CD3– and functional in both nu/nu and Rag2–/– mice. These results implicate IL-7R+ CD3– cells as the direct inducer of the organizing center of PP.
Keywords: development, IL-7R, lymphotoxin, organizing center, Peyer's patch
Transmitting editor: D. Kitamura
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