International Immunology, Vol 10, 371-378, Copyright © 1998 by Oxford University Press
M Papiernik, ML de Moraes, C Pontoux, F Vasseur and C Penit
We recently characterized a CD4+ T cell population expressing the IL-2R
alpha chain (CD25), producing IL-10 and resisting clonal deletion induced
by viral superantigen (vSAG) encoded by mouse mammary tumor virus
[MMTV(SW)]. We now report that these apoptosis-resistant cells are
generated in the thymus but not from the immature CD4+ CD8+ thymocytes.
They migrate from the thymus and are found in the periphery from at least
the 10th day of life, after which they expand with the same kinetics in
normal and MMTV(SW)-infected mice. Their strong capacity for expansion in
the periphery makes this population insensitive to thymectomy in adulthood.
CD4+ CD25+ cells were totally dependent on exogenous IL-2 for growth in
vitro and in vivo, and were missing in IL-2 knockout (KO) mice. The absence
of this population and/or an inability to produce IL-10 may be the missing
link between IL- 2R alpha KO, IL-2 KO and IL-10 KO mice, which all die of
inflammatory bowel disease.
ARTICLES
Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency
INSERM U345, Institut Necker, Paris France.
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I. Caramalho, T. Lopes-Carvalho, D. Ostler, S. Zelenay, M. Haury, and J. Demengeot Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide J. Exp. Med., February 17, 2003; 197(4): 403 - 411. [Abstract] [Full Text] [PDF]
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A. R. M. Almeida, N. Legrand, M. Papiernik, and A. A. Freitas Homeostasis of Peripheral CD4+ T Cells: IL-2R{alpha} and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers J. Immunol., November 1, 2002; 169(9): 4850 - 4860. [Abstract] [Full Text] [PDF]
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D. Dieckmann, C. H. Bruett, H. Ploettner, M. B. Lutz, and G. Schuler Human CD4+CD25+ Regulatory, Contact-dependent T Cells Induce Interleukin 10-producing, Contact-independent Type 1-like Regulatory T Cells J. Exp. Med., July 15, 2002; 196(2): 247 - 253. [Abstract] [Full Text] [PDF]
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A. Banz, C. Pontoux, and M. Papiernik Modulation of Fas-Dependent Apoptosis: A Dynamic Process Controlling Both the Persistence and Death of CD4 Regulatory T Cells and Effector T Cells J. Immunol., July 15, 2002; 169(2): 750 - 757. [Abstract] [Full Text] [PDF]
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 A. G.S. van Halteren, E. van Etten, E. C. de Jong, R. Bouillon, B. O. Roep, and C. Mathieu Redirection of Human Autoreactive T-Cells Upon Interaction With Dendritic Cells Modulated by TX527, an Analog of 1,25 Dihydroxyvitamin D3 Diabetes, July 1, 2002; 51(7): 2119 - 2125. [Abstract] [Full Text] [PDF]
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M. Murakami, A. Sakamoto, J. Bender, J. Kappler, and P. Marrack CD25+CD4+ T cells contribute to the control of memory CD8+ T cells PNAS, June 25, 2002; 99(13): 8832 - 8837. [Abstract] [Full Text] [PDF]
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W. N. D'Souza, K. S. Schluns, D. Masopust, and L. Lefrancois Essential Role for IL-2 in the Regulation of Antiviral Extralymphoid CD8 T Cell Responses J. Immunol., June 1, 2002; 168(11): 5566 - 5572. [Abstract] [Full Text] [PDF]
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A. Le Campion, C. Bourgeois, F. Lambolez, B. Martin, S. Leaument, N. Dautigny, C. Tanchot, C. Penit, and B. Lucas Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexes PNAS, April 2, 2002; 99(7): 4538 - 4543. [Abstract] [Full Text] [PDF]
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L. E. Cheng, C. Ohlen, B. H. Nelson, and P. D. Greenberg Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death PNAS, February 20, 2002; (2002) 52676899. [Abstract] [Full Text] [PDF]
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P. Romagnoli, D. Hudrisier, and J. P. M. van Meerwijk Preferential Recognition of Self Antigens Despite Normal Thymic Deletion of CD4+CD25+ Regulatory T Cells J. Immunol., February 15, 2002; 168(4): 1644 - 1648. [Abstract] [Full Text] [PDF]
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C. Pontoux, A. Banz, and M. Papiernik Natural CD4 CD25+ regulatory T cells control the burst of superantigen-induced cytokine production: the role of IL-10 Int. Immunol., February 1, 2002; 14(2): 233 - 239. [Abstract] [Full Text] [PDF]
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R. Pacholczyk, P. Kraj, and L. Ignatowicz Peptide Specificity of Thymic Selection of CD4+CD25+ T Cells J. Immunol., January 15, 2002; 168(2): 613 - 620. [Abstract] [Full Text] [PDF]
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A. Suto, H. Nakajima, K. Ikeda, S. Kubo, T. Nakayama, M. Taniguchi, Y. Saito, and I. Iwamoto CD4+CD25+ T-cell development is regulated by at least 2 distinct mechanisms Blood, January 15, 2002; 99(2): 555 - 560. [Abstract] [Full Text] [PDF]
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X. Zhang, L. Izikson, L. Liu, and H. L. Weiner Activation of CD25+CD4+ Regulatory T Cells by Oral Antigen Administration J. Immunol., October 15, 2001; 167(8): 4245 - 4253. [Abstract] [Full Text] [PDF]
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J. J. H. Bleesing, M. R. Brown, S. E. Straus, J. K. Dale, R. M. Siegel, M. Johnson, M. J. Lenardo, J. M. Puck, and T. A. Fleisher Immunophenotypic profiles in families with autoimmune lymphoproliferative syndrome Blood, October 15, 2001; 98(8): 2466 - 2473. [Abstract] [Full Text] [PDF]
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K. Nakamura, A. Kitani, and W. Strober Cell Contact-Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface-Bound Transforming Growth Factor {beta} J. Exp. Med., September 3, 2001; 194(5): 629 - 644. [Abstract] [Full Text] [PDF]
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S. J. Bensinger, A. Bandeira, M. S. Jordan, A. J. Caton, and T. M. Laufer Major Histocompatibility Complex Class II-Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells J. Exp. Med., August 20, 2001; 194(4): 427 - 438. [Abstract] [Full Text] [PDF]
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 A. SUTO, H. NAKAJIMA, S.-I. KAGAMI, K. SUZUKI, Y. SAITO, and I. IWAMOTO Role of CD4+ CD25+ Regulatory T Cells in T Helper 2 Cell-mediated Allergic Inflammation in the Airways Am. J. Respir. Crit. Care Med., August 15, 2001; 164(4): 680 - 687. [Abstract] [Full Text] [PDF]
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C. Baecher-Allan, J. A. Brown, G. J. Freeman, and D. A. Hafler CD4+CD25high Regulatory Cells in Human Peripheral Blood J. Immunol., August 1, 2001; 167(3): 1245 - 1253. [Abstract] [Full Text] [PDF]
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E. M. Shevach Certified Professionals: Cd4+Cd25+ Suppressor T Cells J. Exp. Med., June 4, 2001; 193(11): f41 - f46. [Full Text] [PDF]
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H. Jonuleit, E. Schmitt, M. Stassen, A. Tuettenberg, J. Knop, and A. H. Enk Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood J. Exp. Med., June 4, 2001; 193(11): 1285 - 1294. [Abstract] [Full Text] [PDF]
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C.-C. Ku, J. Kappler, and P. Marrack The Growth of the Very Large CD8+ T Cell Clones in Older Mice Is Controlled by Cytokines J. Immunol., February 15, 2001; 166(4): 2186 - 2193. [Abstract] [Full Text] [PDF]
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J. Reddy, P. Chastagner, L. Fiette, X. Liu, and J. Theze IL-2-induced tumor necrosis factor (TNF)-{beta} expression: further analysis in the IL-2 knockout model, and comparison with TNF-{{alpha}}, lymphotoxin-{beta}, TNFR1 and TNFR2 modulation Int. Immunol., February 1, 2001; 13(2): 135 - 147. [Abstract] [Full Text] [PDF]
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J. W. Lindsey and R. Jin Immune regulatory effects of central nervous system antigens in culture Int. Immunol., November 1, 2000; 12(11): 1605 - 1612. [Abstract] [Full Text] [PDF]
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