International Immunology, Vol 10, 371-378, Copyright © 1998 by Oxford University Press
M Papiernik, ML de Moraes, C Pontoux, F Vasseur and C Penit
We recently characterized a CD4+ T cell population expressing the IL-2R
alpha chain (CD25), producing IL-10 and resisting clonal deletion induced
by viral superantigen (vSAG) encoded by mouse mammary tumor virus
[MMTV(SW)]. We now report that these apoptosis-resistant cells are
generated in the thymus but not from the immature CD4+ CD8+ thymocytes.
They migrate from the thymus and are found in the periphery from at least
the 10th day of life, after which they expand with the same kinetics in
normal and MMTV(SW)-infected mice. Their strong capacity for expansion in
the periphery makes this population insensitive to thymectomy in adulthood.
CD4+ CD25+ cells were totally dependent on exogenous IL-2 for growth in
vitro and in vivo, and were missing in IL-2 knockout (KO) mice. The absence
of this population and/or an inability to produce IL-10 may be the missing
link between IL- 2R alpha KO, IL-2 KO and IL-10 KO mice, which all die of
inflammatory bowel disease.
ARTICLES
Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency
INSERM U345, Institut Necker, Paris France.
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J. Huehn, K. Siegmund, J. C.U. Lehmann, C. Siewert, U. Haubold, M. Feuerer, G. F. Debes, J. Lauber, O. Frey, G. K. Przybylski, et al. Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells J. Exp. Med., February 2, 2004; 199(3): 303 - 313. [Abstract] [Full Text] [PDF]
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J. W. Snow, N. Abraham, M. C. Ma, B. G. Herndier, A. W. Pastuszak, and M. A. Goldsmith Loss of Tolerance and Autoimmunity Affecting Multiple Organs in STAT5A/5B-Deficient Mice J. Immunol., November 15, 2003; 171(10): 5042 - 5050. [Abstract] [Full Text] [PDF]
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