International Immunology, Vol 10, 1957-1967, Copyright © 1998 by Oxford University Press
GS Williams, M Malin, D Vremec, CH Chang, R Boyd, C Benoist and D Mathis
We have generated a second line of mice lacking a transcription factor
thought to be a critical regulator of MHC class II gene expression, CIITA
(for class II transactivator). Our and the previously published lines
differ in the deletion that was engineered and by the fact that we removed
the neomycin-resistance promoter and structural gene via the cre-loxP
recombination system. Characterization of our line led to two new findings.
First, a substantial number of cells can express class II molecules in the
absence of CIITA, albeit at 5-fold reduced levels, most notably dendritic
cells in s.c. lymph nodes; therefore, the CIITA gene cannot be an absolute
'master gene' controlling the expression of class II molecules, as had been
thought. Second, in contrast to recent results on human cell lines, CIITA
is not critically involved in the IFN-gamma-induced up-regulation of MHC
class I genes.
ARTICLES
Mice lacking the transcription factor CIITA--a second look [In Process Citation]
Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS/INSERM/ULP), Strasbourg, France.
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