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International Immunology 2009 21(4):NP; doi:10.1093/intimm/dxp036
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© The Japanese Society for Immunology. 2009. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

IN THIS ISSUE

The first 10% of the full text of this article appears below.


    Innate immunity in Japan: a historical perspective
 
In this article, Kaisho and Takeda (p. 313) outline the history of research into innate immunity in Japan. They highlight the many crucial contributions made by Japanese scientists to the field, specifically describing phagocytic cells and innate immune responses in cancer. Finally, they highlight the importance of research in Japan to the burgeoning topic of Toll-like receptors.


    Innate immunity: an update on TLRs, RLRs and NLRs in pathogen recognition
 
Here, Kawai and Akira (p. 317) provide a state-of-the-art review on three types of pattern-recognition receptor (PRR): Toll-like receptors (TLRs), retinoic acid-inducible gene-I-like receptors (RLRs) and nucleotide-binding oligomerization domain-like receptors (NLRs). . . . [Full Text of this Article]


    Bcl-3 inhibits T cell activation and death
 

    Immunization with DNase II leads to DNase and RNase activity
 

    GM-CSF enables DCs to produce retinoic acid
 

    Transplantation tolerance induced by selective Treg expansion
 

    MEKK3 is crucial for T cell function and development
 

    A role for c-Abl in peripheral B cell functions
 

    Natural and pathologic antibodies against topoisomerase I
 

    LFA-1-independent NK cell anti-fungal activity
 

    Responses to NF-L in multiple sclerosis
 

    Recirculating T cells express L-selectin cyclically
 

    Fra-1 regulates LPS-mediated responses
 

    Stromal cell lymphotoxin βR signalling
 

    TRAF2 and TRAF3 are both important for CD40 signalling
 

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