International Immunology, Vol 9, 983-991, Copyright © 1997 by Oxford University Press
M Serwe, G Reuter, A Sponaas, S Koch and N Koch
The invariant chain (Ii) gene encodes two differentially spliced variants
Ii31 and Ii41. The Ii31 isotype is the dominant form expressed in all
antigen-presenting cells (APC). Ii41 is differentially expressed and can be
found in large quantities in Langerhans and dendritic cells. While a
functional role of Ii in class II antigen presentation is now well
established, a distinct role of the Ii isotypes remains controversial. We
tested Ii31 and Ii41 L cell transfectants for antigen presentation of hen
egg lysozyme (HEL) to T cell hybridomas. The result indicates that both Ii
chains promote antigen presentation equally well. To test other APC than
transfected L cells, we introduced a recombinant Ii41 gene into
anti-deficient mouse line. There the transgene induces about one-third of
total li expression of wild-type mice. Surface expression of class II
molecules and the CD4 compartment which are deficient in Ii knock-out mice
are restored in Ii41 transgenic mice. B lymphocytes from Ii41 transgenic
mice and Ii31- expressing B lymphocytes from wild-type mice were used as
APC for presentation of keyhole limpet hemacyanin and ovalbumin to T cell
hybridomas. The results show that both Ii chains facilitate antigen
presentation equally well.
ARTICLES
Both invariant chain isoforms Ii31 and Ii41 promote class II antigen presentation
Section of Immunobiology, Institute of Zoology, University of Bonn, Germany.
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