International Immunology, Vol 9, 1061-1064, Copyright © 1997 by Oxford University Press
V Kronin, D Vremec, K Winkel, BJ Classon, RG Miller, TW Mak, K Shortman and G Suss
The CD8-expressing dendritic cells (DC) present in mouse spleen have been
shown to have a regulatory effect on the CD4 and CD8 T cells they activate,
restricting subsequent T cell proliferation by either inducing apoptotic T
cell death (CD4 T cells) or by limiting endogenous cytokine production (CD8
T cells). To determine the role of the CD8 molecule itself in these
regulatory phenomena, the DC from CD8 null mice were studied. The DC marker
DEC-205 (NLDC 145) was used as a surrogate marker for CD8, since the
expression of these two molecules on splenic DC was closely correlated. DC
levels were normal, and the incidence of DEC-205+ and DEC-205- DC was
normal in CD8 null mice, indicating that the absence of CD8 did not affect
DC development. The proliferative response of T cells to allogeneic
DEC-205+ DC from either CD8-/- or CD8+/+ mice was similar and was much less
than the response to DEC-205- DC from these mice. This applied to both the
CD4 and the CD8 T cell responses. Thus the lack of the CD8 molecule did not
affect the stimulatory or regulatory properties of the DC. The regulatory
CD8+ DEC-205+ DC therefore differ in that respect from antigen-presenting
'veto' cells, where CD8 itself is involved in transmitting negative signals
to the T cells. DEC-205 may prove to be a more pertinent marker of the
regulatory DC population.
ARTICLES
Are CD8+ dendritic cells (DC) veto cells? The role of CD8 on DC in DC development and in the regulation of CD4 and CD8 T cell responses
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
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