International Immunology, Vol 9, 1001-1009, Copyright © 1997 by Oxford University Press
C Jamin, R Le Corre, JO Pers, M Dueymes, PM Lydyard and P Youinou
B cells expressing CD5 also carry its ligand, CD72. As an approach to
understanding the role of CD5 and CD72 on B cells, we have examined the
association of CD72 with CD5 and slgM by modulation/co-modulation and
capping/co-capping following ligation of these surface molecules with
specific antibodies. Modulation and co-modulation were measured after 24 h,
whilst capping was measured after 1 h. CD5 and slgM co-modulated each
other, CD72 co-modulated with slgM and CD5, but anti-CD72 did not affect
either slgM or CD5. CD5 and slgM co-capped each other, whilst CD72 failed
to co-cap with either slgM or CD5. The CD5-induced co- modulation of CD72
was partially blocked by specific protein tyrosine kinase inhibitor, but
not the slgM-induced co-modulation, Protein kinase C (PKC) inhibitors
abrogated the anti-mu- but not the anti-CD5- triggered modulation of CD72,
whereas PKC activators prevented the CD5- but not the slgM-induced 24 h
modulation of CD72. None of these drugs was able to modify the
anti-CD72-induced modulation of CD72. Our data suggest that CD5 is
physically associated with slgM in the B cell receptor complex but not with
CD72. Furthermore, from the effect of drugs on modulation, there appears to
be different associations of CD72 with slgM and CD5. These two pathways
differed in some respects, consistent with a co-stimulatory function of
CD72 and CD5 in B cell activation.
ARTICLES
Modulation of CD72 by ligation of B cell receptor complex molecules on CD5+ B cells
Laboratory of Immunology, Brest University Medical School Hospital, France.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  H.-J. Wu, C. Venkataraman, S. Estus, C. Dong, R. J. Davis, R. A. Flavell, and S. Bondada Positive Signaling Through CD72 Induces Mitogen-Activated Protein Kinase Activation and Synergizes with B Cell Receptor Signals to Induce X-Linked Immunodeficiency B Cell Proliferation J. Immunol., August 1, 2001; 167(3): 1263 - 1273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Adachi, C. Wakabayashi, T. Nakayama, H. Yakura, and T. Tsubata CD72 Negatively Regulates Signaling Through the Antigen Receptor of B Cells J. Immunol., February 1, 2000; 164(3): 1223 - 1229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Adachi, H. Flaswinkel, H. Yakura, M. Reth, and T. Tsubata Cutting Edge: The B Cell Surface Protein CD72 Recruits the Tyrosine Phosphatase SHP-1 upon Tyrosine Phosphorylation J. Immunol., May 15, 1998; 160(10): 4662 - 4665. [Abstract] [Full Text] [PDF]
|
|