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International Immunology, Vol 9, 843-851, Copyright © 1997 by Oxford University Press

ARTICLES

CD4 and CD8 expressions in African green monkey helper T lymphocytes: implication for resistance to SIV infection

Y Murayama, A Amano, R Mukai, H Shibata, S Matsunaga, H Takahashi, Y Yoshikawa, M Hayami and A Noguchi
Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki- ken, Japan.

We found that most peripheral CD4 cells co-express a low density of CD8 alpha antigen in African green monkeys (AGM). Further, the cell surface expression of CD4 and the expression of CD4 mRNA underwent a decrease when purified CD4CD8low cells were cultured with mitogen and IL-2. These observations suggest that AGM CD4 cells are subject to loss of CD4 expression after lymphocyte activation. Part of the peripheral CD8 fraction exhibited a significant helper activity which suggested the phenotypic conversion in helper T cells from CD4+ to CD4- in vivo. Simian immunodeficiency virus (SIV) grew well in CD4 panning cells following SIV infection. In contrast, CD4CD8low cells were resistant to SIV infection after their conversion to CD4- cells.
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