International Immunology, Vol 9, 1601-1605, Copyright © 1997 by Oxford University Press
C Koniaras, SR Bennett, FR Carbone, WR Heath and AM Lew
The ultimate fate of T cells undergoing antigen-induced cell death in vivo
remains controversial. Whereas apoptosis of CD4+ T cells driven by
superantigen is readily detectable in lymphoid organs, CD8+ T cells have
been reported to disappear from the lymphoid organs and accumulate in the
liver where they undergo apoptosis. Using transgenic mice that produce
large numbers of ovalbumin-specific CD8+ T cells (OT-I cells), we were able
to investigate the events that follow soluble peptide administration in an
independent CD8+ T cell system. Here we show that the OT-I cells undergo
proliferation and apoptosis in situ in lymphoid organs in response to
antigenic stimulation with no evidence for liver involvement. This is
similar to the course of events found for CD4+ T cell activation and
counters the view that the liver is a general site for CD8+ T cell
clearance following antigen-specific activation.
ARTICLES
Peptide-induced deletion of CD8 T cells in vivo occurs via apoptosis in situ
Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia.
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