International Immunology, Vol 9, 1523-1526, Copyright © 1997 by Oxford University Press
O Kanagawa, J Shimizu and ER Unanue
We examine here how the beta chain of the class II MHC molecule I-Ag7
influences T cell recognition. Three sets of T cell clones were identified.
The first set recognizes peptides bound to I-Ag7, I-Ad and I-Ag7 mutant in
which the allele-specific residues His and Ser at position 56 and 57 were
changed to the Pro at residue 56 and to non- polymorphic Asp at residue 57.
The second set responds to the antigen presented only by I-Ag7 and does not
recognize the peptides bound to the other class II molecules. The third set
is also specific for I-Ag7 as a result of the poor binding of the peptide
to I-Ad and the mutant I- Ag7. These results indicate that positions 56 and
57 of the I-Ag7 class II MHC beta chain play a role in both T cell
recognition of the MHC- peptide complex and peptide binding to MHC. These
two different functions may be involved in I-Ag7-restricted beta cell
antigen recognition by diabetogenic T cell clones.
ARTICLES
The role of I-Ag7 beta chain in peptide binding and antigen recognition by T cells
Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA.
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