International Immunology, Vol 9, 1481-1494, Copyright © 1997 by Oxford University Press
DM Tarlinton, LM Corcoran and A Strasser
During B lymphopoiesis, cells undergo successive rounds of division and
growth arrest coupled to intermittent selection on the basis of Ig
expression. It is unresolved whether differentiation requires specific
signaling or is merely the consequence of sustained cell survival.
Transgenic expression of the cell death antagonist, Bcl-2, promoted
accumulation of B lymphoid cells in mice deficient in antigen receptor
rearrangement (scid or rag-1-/-) and in mice lacking the IgM transmembrane
domain (microMT). Continued differentiation occurred, however, only in the
bcl-2/scid and bcl-2/microMT mice. The appearance of B lineage cells
expressing CD21, CD22 and CD23 was associated with DHJH rearrangements
which encode a truncated C mu-containing protein called D mu in bcl-2/scid
mice and with expression of Ig heavy chain classes other than IgM in the
bcl-2/ microMT mice. In neither case, however, were proliferating cells
observed in the more mature B lineage compartments in the bone marrow.
Thus, continued B cell development requires signaling via Ig heavy
chain-containing receptors and is not simply a consequence of blocking
apoptosis.
ARTICLES
Continued differentiation during B lymphopoiesis requires signals in addition to cell survival
Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia.
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